Efficient tuberculosis treatment in mice using chemotherapy and   immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and   MPT-83

doi:10.1038/dt.2008.13

CORC > 北京大学 > 生命科学学院

	Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83
	Yu, D-H ; Hu, X-D ; Cai, H.
刊名	gene therapy
	2008
关键词	mycobacterium tuberculosis combined DNA vaccine immunotherapeutic effect INH plus PZA MYCOBACTERIUM-TUBERCULOSIS INTERFERON-GAMMA MOLECULAR EPIDEMIOLOGY EXOGENOUS REINFECTION PROTECTIVE EFFICACY INFECTION THERAPY IMMUNOLOGY RESISTANCE IMMUNITY
DOI	10.1038/dt.2008.13
英文摘要	Although most cases of tuberculosis ( TB) can be cured with antibiotics, relapse is common if patients do not continue chemotherapy for at least 6 months. Thus, improved therapeutic strategies are urgently needed. We previously found that the combined DNA vaccine encoding the Mycobacterium tuberculosis proteins Ag85B, MPT- 64 and MPT- 83 protected mice from TB following H37Rv challenge and considered whether this combined DNA vaccine has a therapeutic effect. In the present work, we demonstrate that boosting the efficiency of the immune system with the combined DNA vaccine may be a valuable adjunct to shorten the duration of antibacterial chemotherapy. Mice treated with the combined DNA vaccine along with isoniazid and pyrazinamide showed significantly higher interferon-gamma responses to a mixture of the three specific antigens ( P < 0.001), which were accompanied by a significant reduction in colony-forming unit in H37Rv-infected animals 3-5 months after treatment ( P < 0.001). These results suggest that the combined DNA vaccine along with conventional TB chemotherapy has strong potential for TB immunotherapy and may provide new alternatives to control the disease.; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental; SCI(E); PubMed; 14; ARTICLE; 9; 652-659; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/320026]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yu, D-H,Hu, X-D,Cai, H.. Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83[J]. gene therapy,2008.
APA	Yu, D-H,Hu, X-D,&Cai, H..(2008).Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83.gene therapy.
MLA	Yu, D-H,et al."Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83".gene therapy (2008).