Negative feedback regulation of cellular antiviral signaling by   RBCK1-mediated degradation of IRF3

doi:10.1038/cr.2008.277

CORC > 北京大学 > 生命科学学院

	Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
	Zhang, Min ; Tian, Yang ; Wang, Rui-Peng ; Gao, Dong ; Zhang, Yan ; Diao, Fei-Ci ; Chen, Dan-Ying ; Zhai, Zhong-He ; Shu, Hong-Bing
刊名	细胞研究英文版
	2008
关键词	RBCK1 IRF3 antiviral response type I IFNs feedback regulation E3 ligase E3 UBIQUITIN LIGASE RNA HELICASE LGP2 INDUCIBLE GENE-I NF-KAPPA-B RIG-I TRANSCRIPTION FACTOR AUTOIMMUNE-DISEASES INTERFERON RESPONSE ADAPTER PROTEIN VIRUS
DOI	10.1038/cr.2008.277
英文摘要	Viral infection causes host cells to produce type I interferons (IFNs), which are critically involved in viral clearance. Previous studies have demonstrated that activation of the transcription factor interferon regulatory factor (IRF) 3 is essential for virus-triggered induction of type I IFNs. Here we show that the E3 ubiquitin ligase RBCC protein interacting with PKC1 (RBCK1) catalyzes the ubiquitination and degradation of IRF3. Overexpression of RBCK1 negatively regulates Sendai virus-triggered induction of type I IFNs, while knockdown of RBCK1 has the opposite effect. Plaque assays consistently demonstrate that RBCK1 negatively regulates the cellular antiviral response. Furthermore, viral infection leads to induction of RBCK1 and subsequent degradation of IRF3. These findings suggest that the cellular antiviral response is controlled by a negative feedback regulatory mechanism involving RBCK1-mediated ubiquitination and degradation of IRF3.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000261817700004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 56; ARTICLE; 11; 1096-1104; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/320001]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Min,Tian, Yang,Wang, Rui-Peng,et al. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3[J]. 细胞研究英文版,2008.
APA	Zhang, Min.,Tian, Yang.,Wang, Rui-Peng.,Gao, Dong.,Zhang, Yan.,...&Shu, Hong-Bing.(2008).Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.细胞研究英文版.
MLA	Zhang, Min,et al."Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3".细胞研究英文版 (2008).