WDR34 is a novel TAK1-associated suppressor of the   IL-1R/TLR3/TLR4-induced NF-kappa B activation pathway

doi:10.1007/s00018-009-0059-6

CORC > 北京大学 > 生命科学学院

	WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappa B activation pathway
	Gao, Dong ; Wang, Ruipeng ; Li, Bingfeng ; Yang, Yongkang ; Zhai, Zhonghe ; Chen, Dan-Ying
刊名	cellular and molecular life sciences
	2009
关键词	TAK1 WDR34 IL-1R TLR4 TLR3 NF-kappa B BETA SIGNAL-TRANSDUCTION INNATE IMMUNE-RESPONSES KINASE KINASE KINASE TAK1 MAPKKK TAK1-BINDING PROTEIN-1 CRITICAL ROLES TAB1 IL-1 DROSOPHILA BINDING
DOI	10.1007/s00018-009-0059-6
英文摘要	Toll-like receptors (TLRs) act as sensors of microbial components and elicit innate immune responses. All TLR signaling pathways activate the nuclear factor-kappaB (NF-kappa B), which controls the expression of inflammatory cytokine genes. Transforming growth factor-beta-activated kinase 1 (TAK1) is a serine/threonine protein kinase that is critically involved in the activation of NF-kappa B by tumor necrosis factor (TNF alpha), interleukin-1 beta (IL-1 beta) and TLR ligands. In this study, we identified a novel protein, WD40 domain repeat protein 34 (WDR34) as a TAK1-interacting protein in yeast two-hybrid screens. WDR34 interacted with TAK1, TAK1-binding protein 2 (TAB2), TAK1-binding protein 3 (TAB3) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in overexpression and under physiological conditions. Overexpression of WDR34 inhibited IL-1 beta-, polyI:C- and lipopolysaccharide (LPS)-induced but not TNF alpha-induced NF-kappa B activation, whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-kappa B activation by these ligands. Our findings suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-kappa B activation pathway.; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 6; ARTICLE; 15; 2573-2584; 66
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319987]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gao, Dong,Wang, Ruipeng,Li, Bingfeng,et al. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappa B activation pathway[J]. cellular and molecular life sciences,2009.
APA	Gao, Dong,Wang, Ruipeng,Li, Bingfeng,Yang, Yongkang,Zhai, Zhonghe,&Chen, Dan-Ying.(2009).WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappa B activation pathway.cellular and molecular life sciences.
MLA	Gao, Dong,et al."WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappa B activation pathway".cellular and molecular life sciences (2009).