Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary   Neurons

doi:10.3233/JAD-2010-1246

CORC > 北京大学 > 生命科学学院

	Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary Neurons
	Cui, Jia ; Chen, Qiuyue ; Yue, Xiaojing ; Jiang, Xuejun ; Gao, George F. ; Yu, Long-Chuan ; Zhang, Yan
刊名	journal of alzheimers disease
	2010
关键词	Alzheimer&apos galanin human primary neurons neuronal loss PRIMARY SENSORY NEURONS ALZHEIMERS-DISEASE TRANSGENIC MICE A-BETA PRECURSOR PROTEIN GENE-EXPRESSION A-BETA-42 ACCUMULATION RECEPTOR ANTAGONISTS VENTRAL HIPPOCAMPUS COGNITIVE DEFICITS s disease
DOI	10.3233/JAD-2010-1246
英文摘要	Galanin and galanin receptors are upregulated in the brain regions associated with Alzheimer's disease (AD). However, the consequence of this overexpression is still unknown, particularly in human neurons. Here, we investigate the possible protective effects of galanin against intracellular amyloid-beta (A beta)(1-42) toxicity, as well as other insults including staurosporine, etoposide, hydrogen peroxide, and serum depletion in cultured human primary neurons. The results show that galanin is protective against intracellular A beta cytotoxicity and all of the above insults at sub-nanomolar physiological concentrations. The galanin protection may be mediated by galanin receptor 2 and down-regulation of Bax level. The data from the present study provide a potential drug target for therapy or prevention of neurodegenerative diseases, including AD.; Neurosciences; SCI(E); PubMed; 10; ARTICLE; 2; 529-544; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319984]
专题	生命科学学院
推荐引用方式 GB/T 7714	Cui, Jia,Chen, Qiuyue,Yue, Xiaojing,et al. Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary Neurons[J]. journal of alzheimers disease,2010.
APA	Cui, Jia.,Chen, Qiuyue.,Yue, Xiaojing.,Jiang, Xuejun.,Gao, George F..,...&Zhang, Yan.(2010).Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary Neurons.journal of alzheimers disease.
MLA	Cui, Jia,et al."Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary Neurons".journal of alzheimers disease (2010).