Oral immunogenicity of potato-derived antigens to Mycobacterium   tuberculosis in mice

doi:10.1093/abbs/gms068

CORC > 北京大学 > 生命科学学院

	Oral immunogenicity of potato-derived antigens to Mycobacterium tuberculosis in mice
	Zhang, Yi ; Chen, Suting ; Li, Jiayun ; Liu, Yuan ; Hu, Yuanlei ; Cai, Hong
刊名	acta biochimica et biophysica sinica
	2012
关键词	tuberculosis vaccine mucosal delivery transgenic plants COMBINED DNA VACCINES PROTECTIVE IMMUNITY PULMONARY TUBERCULOSIS TRANSGENIC PLANTS BRUCELLA-ABORTUS BCG VACCINATION BOVIS BCG IMMUNIZATION MUCOSAL INFECTION
DOI	10.1093/abbs/gms068
英文摘要	The novel use of transgenic plants as vectors for the expression of viral and bacterial antigens has been increasingly tested as an alternative methodology for the production and delivery of experimental oral vaccines. Here, we examined the immunogenicity of combined plant-made vaccines that include four genes encoding immune-dominant antigens from Mycobacterium tuberculosis. Compared with the wild type and other control groups, mice treated with the combined plant-made vaccines showed significantly higher levels of interferon-g and interleukin-2 production in response to all four proteins, and higher levels of antigen-specific CD4(+) and CD8(+) T-cell responses and immunoglobulin (Ig) G and IgA titers. These results suggest that combined plant-made vaccines can induce immunogenicity against M. tuberculosis through the induction of stronger Th1-associated immune responses. This is the first report of an orally delivered combined plant-made vaccine against tuberculosis priming an antigen-specific Th1 response, a comprehensive effect including both mucosal and systemic immune responses.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310370500003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Biophysics; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 4; ARTICLE; 10; 823-830; 44
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319943]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Yi,Chen, Suting,Li, Jiayun,et al. Oral immunogenicity of potato-derived antigens to Mycobacterium tuberculosis in mice[J]. acta biochimica et biophysica sinica,2012.
APA	Zhang, Yi,Chen, Suting,Li, Jiayun,Liu, Yuan,Hu, Yuanlei,&Cai, Hong.(2012).Oral immunogenicity of potato-derived antigens to Mycobacterium tuberculosis in mice.acta biochimica et biophysica sinica.
MLA	Zhang, Yi,et al."Oral immunogenicity of potato-derived antigens to Mycobacterium tuberculosis in mice".acta biochimica et biophysica sinica (2012).