Tunneling-nanotube direction determination in neurons and astrocytes

doi:10.1038/cddis.2012.177

CORC > 北京大学 > 生命科学学院

	Tunneling-nanotube direction determination in neurons and astrocytes
	Sun, X. ; Wang, Y. ; Zhang, J. ; Tu, J. ; Wang, X-J ; Su, X-D ; Wang, L. ; Zhang, Y.
刊名	cell death disease
	2012
关键词	tunneling nanotube direction S100A4 caspase-3 cell death MEMBRANE NANOTUBES PLASMA-MEMBRANE IMMUNE CELLS S100 PROTEINS COMMUNICATION CONNECTIONS METASTASIS TRANSPORT CYTONEMES RAGE
DOI	10.1038/cddis.2012.177
英文摘要	A tunneling nanotube (TNT) is a newly discovered structure involved in cell-cell communication and is found in various types of cells. Here we identify S100A4 as an extracellular molecule and describe its role in attracting the growth direction of TNTs. Together with its putative receptor, receptor for advanced glycation end product, we demonstrate their involvement in TNT direction guidance. Our results further suggest a mechanism for direction guidance of TNTs. In TNT-initiating cells, p53 activates caspase-3, which leads to S100A4 cleavage and its subsequent decrease in cellular concentration. The decrease in cellular S100A4 induces the formation of a gradient of S100A4, from a low concentration in initiating cells toward a high concentration in target cells. This concentration gradient of S100A4 induces direction guidance for TNTs. Cell Death and Disease (2012) 3, e438; doi:10.1038/cddis.2012.177; published online 6 December 2012; Cell Biology; SCI(E); PubMed; 7; ARTICLE; e438; 3
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319941]
专题	生命科学学院
推荐引用方式 GB/T 7714	Sun, X.,Wang, Y.,Zhang, J.,et al. Tunneling-nanotube direction determination in neurons and astrocytes[J]. cell death disease,2012.
APA	Sun, X..,Wang, Y..,Zhang, J..,Tu, J..,Wang, X-J.,...&Zhang, Y..(2012).Tunneling-nanotube direction determination in neurons and astrocytes.cell death disease.
MLA	Sun, X.,et al."Tunneling-nanotube direction determination in neurons and astrocytes".cell death disease (2012).