Pluripotent Stem Cells Induced from Mouse Somatic Cells by   Small-Molecule Compounds

doi:10.1126/science.1239278

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	Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
	Hou, Pingping ; Li, Yanqin ; Zhang, Xu ; Liu, Chun ; Guan, Jingyang ; Li, Honggang ; Zhao, Ting ; Ye, Junqing ; Yang, Weifeng ; Liu, Kang ; Ge, Jian ; Xu, Jun ; Zhang, Qiang ; Zhao, Yang ; Deng, Hongkui
刊名	science
	2013
关键词	S-ADENOSYLHOMOCYSTEINE HYDROLASE REGENERATIVE MEDICINE STATE
DOI	10.1126/science.1239278
英文摘要	Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clinical applications. Here, we show that pluripotent stem cells can be generated from mouse somatic cells at a frequency up to 0.2% using a combination of seven small-molecule compounds. The chemically induced pluripotent stem cells resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. By using small molecules, exogenous "master genes" are dispensable for cell fate reprogramming. This chemical reprogramming strategy has potential use in generating functional desirable cell types for clinical applications.; Multidisciplinary Sciences; SCI(E); PubMed; 210; ARTICLE; 6146; 651-654; 341
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319928]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hou, Pingping,Li, Yanqin,Zhang, Xu,et al. Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds[J]. science,2013.
APA	Hou, Pingping.,Li, Yanqin.,Zhang, Xu.,Liu, Chun.,Guan, Jingyang.,...&Deng, Hongkui.(2013).Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds.science.
MLA	Hou, Pingping,et al."Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds".science (2013).