The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling   Arabidopsis ovule development

doi:10.1038/cr.2014.145

CORC > 北京大学 > 生命科学学院

	The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development
	Wei, Baoye ; Zhang, Jinzhe ; Pang, Changxu ; Yu, Hao ; Guo, Dongshu ; Jiang, Hao ; Ding, Mingxin ; Chen, Zhuoyao ; Tao, Qing ; Gu, Hongya ; Qu, Li-Jia ; Qin, Genji
刊名	细胞研究英文版
	2015
关键词	SPOROCYTELESS/NOZZLE transcriptional repressor TPL/TPR co-repressors TCP transcription factors sporogenesis TCP TRANSCRIPTION FACTORS CO-REPRESSOR TOPLESS PATTERN-FORMATION SACCHAROMYCES-CEREVISIAE LEAF DEVELOPMENT GAMETOPHYTE DEVELOPMENT FEMALE GAMETOPHYTE EARLY SPOROGENESIS FLOWERING PLANTS PROXIMAL-DISTAL
DOI	10.1038/cr.2014.145
英文摘要	Ovules are essential for plant reproduction and develop into seeds after fertilization. SPOROCYTELESS/NOZZLE (SPL/NZZ) has been known for more than 15 years as an essential factor for ovule development in Arabidopsis, but the biochemical nature of SPL function has remained unsolved. Here, we demonstrate that SPL functions as an adaptor-like transcriptional repressor. We show that SPL recruits TOPLESS/TOPLESS-RELATED (TPL/TPR) co-repressors to inhibit the CINCINNATA (CIN)-like TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors. We reveal that SPL uses its EAR motif at the C-terminal end to recruit TPL/TPRs and its N-terminal part to bind and inhibit the TCPs. We demonstrate that either disruption of TPL/TPRs or overexpression of TCPs partially phenocopies the defects of megasporogenesis in spl. Moreover, disruption of TCPs causes phenotypes that resemble spl-D gain-of-function mutants. These results define the action mechanism for SPL, which along with TPL/TPRs controls ovule development by repressing the activities of key transcription factors. Our findings suggest that a similar gene repression strategy is employed by both plants and fungi to control sporogenesis.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349330800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 6; ARTICLE; qingenji@pku.edu.cn; 1; 121-134; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319916]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wei, Baoye,Zhang, Jinzhe,Pang, Changxu,et al. The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development[J]. 细胞研究英文版,2015.
APA	Wei, Baoye.,Zhang, Jinzhe.,Pang, Changxu.,Yu, Hao.,Guo, Dongshu.,...&Qin, Genji.(2015).The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development.细胞研究英文版.
MLA	Wei, Baoye,et al."The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development".细胞研究英文版 (2015).