Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct   phosphorylated forms of phytochrome a in balancing light signaling

doi:10.1016/j.molcel.2008.08.003

CORC > 北京大学 > 生命科学学院

	Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome a in balancing light signaling
	Saijo, Yusuke ; Zhu, Danmeng ; Li, Jigang ; Rubio, Vicente ; Zhou, Zhenzhen ; Shen, Yunping ; Hoecker, Ute ; Wang, Haiyang ; Deng, Xing Wang
刊名	分子细胞
	2008
关键词	TRANSCRIPTION FACTOR HIGHER-PLANTS PHOTOMORPHOGENESIS DEGRADATION FHY1 COP1 UBIQUITINATION TRANSDUCTION SUPPRESSION PROTEOLYSIS
DOI	10.1016/j.molcel.2008.08.003
英文摘要	Fine tuning of light signaling is crucial to plant development. Following light-triggered nuclear translocation, the photoreceptor phytochrome A (phyA) regulates gene expression under continuous far-red light and is rapidly destabilized upon red light irradiation by E3 ubiquitin ligases, including COP1. Here we provide evidence that the light signaling repressors SPA proteins contribute to COP1-mediated phyA degradation and that a COP1/SPA1 protein complex is tightly associated with phyA ubiquitination activity. Furthermore, a phosphorylated phyA form accumulates in the nucleus and preferentially associates with the COP1/SPA1 complex. In contrast, underphosphorylated phyA predominantly associates with the phyA-signaling intermediates FHY3 and FHY1. However, COP1 associates with underphosphorylated phyA in the absence of FHY3 or FHY1, suggesting that phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex. We propose that light-induced phyA phosphorylation acts as a switch controlling differential interactions of the photoreceptor with signal propagation or attenuation machineries.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258744100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; SCI(E); 57; ARTICLE; 4; 607-613; 31
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/290132]
专题	生命科学学院
推荐引用方式 GB/T 7714	Saijo, Yusuke,Zhu, Danmeng,Li, Jigang,et al. Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome a in balancing light signaling[J]. 分子细胞,2008.
APA	Saijo, Yusuke.,Zhu, Danmeng.,Li, Jigang.,Rubio, Vicente.,Zhou, Zhenzhen.,...&Deng, Xing Wang.(2008).Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome a in balancing light signaling.分子细胞.
MLA	Saijo, Yusuke,et al."Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome a in balancing light signaling".分子细胞 (2008).