Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications | |
Xiao, RP ; Zhu, WZ ; Zheng, M ; Chakir, K ; Bond, R ; Lakatta, EG ; Cheng, HP | |
刊名 | trends in pharmacological sciences
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2004 | |
关键词 | RAT VENTRICULAR MYOCYTES ADRENERGIC-RECEPTOR KINASE CARDIAC G(S-ALPHA) OVEREXPRESSION HUMAN BETA(1)-ADRENERGIC RECEPTOR ACUTE MYOCARDIAL-INFARCTION FACTOR GENE-EXPRESSION TREATED GUINEA-PIGS FAILING HUMAN HEART BETA(2)-ADRENERGIC RECEPTOR G-PROTEIN |
DOI | 10.1016/j.tips.2004.05.007 |
英文摘要 | beta-Adrenoceptor stimulation serves as the most powerful means to increase cardiac output in response to stress or exercise. However, sustained beta(2)-adrenoceptor stimulation promotes pathological cardiac remodeling such as myocyte hypertrophy and apoptosis, thus contributing to heart failure. Coexisting cardiac beta-adrenoceptor subtypes, mainly beta(1)-adrenoceptors and beta(2)-adrenoceptors, activate different signaling cascades with beta(1)-adrenoceptors coupling to G(s) and beta(2)-adrenoceptors coupling to G(s) and G(i) pathways. As a result, sustained beta(2)-adrenoceptor stimulation protects cardiomyocytes against apoptosis via a G(1)-phosphatidylinositol 3-kinaseprotein kinase B pathway, whereas chronic beta(1)-adrenoceptor stimulation induces myocyte hypertrophy and apoptosis by protein kinase A-independent activation of calmodullin kinase II signaling. These advances in our understanding of beta-adrenoceptor subtype signaling identify the mechanisms that underlie the beneficial effects of beta-adrenoceptor antagonists and delineate the rationale for combining beta(1)-adrenoceptor blockade with beta(2)-adrenoceptor activation as a potential therapy for heart failure.; Pharmacology & Pharmacy; SCI(E); 0; REVIEW; 7; 358-365; 25 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/254898] ![]() |
专题 | 生命科学学院 |
推荐引用方式 GB/T 7714 | Xiao, RP,Zhu, WZ,Zheng, M,et al. Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications[J]. trends in pharmacological sciences,2004. |
APA | Xiao, RP.,Zhu, WZ.,Zheng, M.,Chakir, K.,Bond, R.,...&Cheng, HP.(2004).Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.trends in pharmacological sciences. |
MLA | Xiao, RP,et al."Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications".trends in pharmacological sciences (2004). |
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