Subtype-specific beta-adrenoceptor signaling pathways in the heart and   their potential clinical implications

doi:10.1016/j.tips.2004.05.007

CORC > 北京大学 > 生命科学学院

	Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
	Xiao, RP ; Zhu, WZ ; Zheng, M ; Chakir, K ; Bond, R ; Lakatta, EG ; Cheng, HP
刊名	trends in pharmacological sciences
	2004
关键词	RAT VENTRICULAR MYOCYTES ADRENERGIC-RECEPTOR KINASE CARDIAC G(S-ALPHA) OVEREXPRESSION HUMAN BETA(1)-ADRENERGIC RECEPTOR ACUTE MYOCARDIAL-INFARCTION FACTOR GENE-EXPRESSION TREATED GUINEA-PIGS FAILING HUMAN HEART BETA(2)-ADRENERGIC RECEPTOR G-PROTEIN
DOI	10.1016/j.tips.2004.05.007
英文摘要	beta-Adrenoceptor stimulation serves as the most powerful means to increase cardiac output in response to stress or exercise. However, sustained beta(2)-adrenoceptor stimulation promotes pathological cardiac remodeling such as myocyte hypertrophy and apoptosis, thus contributing to heart failure. Coexisting cardiac beta-adrenoceptor subtypes, mainly beta(1)-adrenoceptors and beta(2)-adrenoceptors, activate different signaling cascades with beta(1)-adrenoceptors coupling to G(s) and beta(2)-adrenoceptors coupling to G(s) and G(i) pathways. As a result, sustained beta(2)-adrenoceptor stimulation protects cardiomyocytes against apoptosis via a G(1)-phosphatidylinositol 3-kinaseprotein kinase B pathway, whereas chronic beta(1)-adrenoceptor stimulation induces myocyte hypertrophy and apoptosis by protein kinase A-independent activation of calmodullin kinase II signaling. These advances in our understanding of beta-adrenoceptor subtype signaling identify the mechanisms that underlie the beneficial effects of beta-adrenoceptor antagonists and delineate the rationale for combining beta(1)-adrenoceptor blockade with beta(2)-adrenoceptor activation as a potential therapy for heart failure.; Pharmacology & Pharmacy; SCI(E); 0; REVIEW; 7; 358-365; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/254898]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xiao, RP,Zhu, WZ,Zheng, M,et al. Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications[J]. trends in pharmacological sciences,2004.
APA	Xiao, RP.,Zhu, WZ.,Zheng, M.,Chakir, K.,Bond, R.,...&Cheng, HP.(2004).Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.trends in pharmacological sciences.
MLA	Xiao, RP,et al."Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications".trends in pharmacological sciences (2004).