Chaperone-like activity of beta-casein

doi:10.1016/j.biocel.2004.12.004

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	Chaperone-like activity of beta-casein
	Zhang, XF ; Fu, XM ; Zhang, H ; Liu, C ; Jiao, WW ; Chang, ZY
刊名	international journal of biochemistry cell biology
	2005
关键词	beta-casein chaperone protein aggregation hydrophobic FUNCTIONAL-PROPERTIES MOLECULAR CHAPERONES SERINE-PROTEASE MILK-PROTEINS AGGREGATION SUBSTRATE HTRA REACTIVATION TUBULIN BINDING
DOI	10.1016/j.biocel.2004.12.004
英文摘要	The caseins are major components of milk for most mammals and are secreted as large colloidal aggregates termed micelles. They have less ordered secondary and tertiary structures in comparison with typical globular proteins. In this work, beta-casein, a member of the casein family, has been demonstrated to exhibit chaperone-like activity, being able to suppress the thermal and chemical aggregation of such substrate proteins as insulin, lysozyme, alcohol dehydrogenase, and catalase by forming stable complexes with the denaturing substrate proteins. Meanwhile, beta-casein was found to not only prevent aggregation of the substrate proteins, but also solubilize the protein aggregates already formed. Data also show that P-casein exhibits a higher chaperone-like activity than a-casein, likely due to the difference in the number of proline residues present and/or in the extent of exposed hydrophobic surfaces. The implications for their in vivo functions of the caseins, based on their exhibiting such in vitro chaperone-like activities, are discussed. (c) 2004 Elsevier Ltd. All rights reserved.; Biochemistry & Molecular Biology; Cell Biology; SCI(E); 49; ARTICLE; 6; 1232-1240; 37
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/253431]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, XF,Fu, XM,Zhang, H,et al. Chaperone-like activity of beta-casein[J]. international journal of biochemistry cell biology,2005.
APA	Zhang, XF,Fu, XM,Zhang, H,Liu, C,Jiao, WW,&Chang, ZY.(2005).Chaperone-like activity of beta-casein.international journal of biochemistry cell biology.
MLA	Zhang, XF,et al."Chaperone-like activity of beta-casein".international journal of biochemistry cell biology (2005).