YY1 repressing peroxisome proliferator-activated receptor delta promoter

doi:10.1007/s11010-007-9632-1

CORC > 北京大学 > 生命科学学院

	YY1 repressing peroxisome proliferator-activated receptor delta promoter
	He, Cheng-Qiang ; Ding, Nai-Zheng ; Fan, Wei
刊名	molecular and cellular biochemistry
	2008
关键词	PPAR delta YY1 promoter TRANSCRIPTIONAL REPRESSION PPAR-DELTA COLORECTAL-CANCER POLYMERASE-II BETA/DELTA EXPRESSION YIN-YANG-1 BINDING PROTEIN CELLS
DOI	10.1007/s11010-007-9632-1
英文摘要	Peroxisome proliferator-activated receptors delta (PPAR delta) is a nuclear hormone receptor belonging to the steroid receptor superfamily and is molecular targets for drugs to treat hypertriglyceridemia and type 2 diabetes. Yin Yang 1 (YY1) is a transcription factor that can repress or activate transcription of the genes with which it interacts. In this report, we show that YY1 specifically interacts with the PPAR delta promoter. Overexpression of YY1 in Hela and NIH 3T3 cells repressed the activity of the PPAR delta promoter, while the PPAR delta promoter activity was enhanced when YY1 was knocked down by siRNA YY1. We also show that YY1 in nuclear extracts was able to bind the PPAR delta promoter directly. These results suggest that YY1 might be a negative regulator of PPAR delta gene expression through its direct interaction with the PPAR delta promoter.; Cell Biology; SCI(E); 5; ARTICLE; 1-2; 247-252; 308
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/249475]
专题	生命科学学院
推荐引用方式 GB/T 7714	He, Cheng-Qiang,Ding, Nai-Zheng,Fan, Wei. YY1 repressing peroxisome proliferator-activated receptor delta promoter[J]. molecular and cellular biochemistry,2008.
APA	He, Cheng-Qiang,Ding, Nai-Zheng,&Fan, Wei.(2008).YY1 repressing peroxisome proliferator-activated receptor delta promoter.molecular and cellular biochemistry.
MLA	He, Cheng-Qiang,et al."YY1 repressing peroxisome proliferator-activated receptor delta promoter".molecular and cellular biochemistry (2008).