SIPAR negatively regulates STAT3 signaling and inhibits progression of   melanoma

doi:10.1016/j.cellsig.2013.07.023

CORC > 北京大学 > 生命科学学院

	SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma
	Ren, Fangli ; Su, Fuqin ; Ning, Hongxiu ; Wang, Yangmeng ; Geng, Yongtao ; Feng, Yarui ; Wang, Yinyin ; Zhang, Yanquan ; Jin, Zhe ; Li, Yi ; Jia, Baoqing ; Chang, Zhijie
刊名	cellular signalling
	2013
关键词	SIPAR STAT3 Dephosphorylation Melanoma EPIDERMAL-GROWTH-FACTOR CONSTITUTIVE ACTIVATION MOLECULAR TARGETS SUPPRESSES GROWTH CANCER-THERAPY BREAST-CANCER CELL-GROWTH IN-VIVO APOPTOSIS SRC
DOI	10.1016/j.cellsig.2013.07.023
英文摘要	Persistently activated STAT3 is important for tumorigenesis in a variety of cancers, including melanoma. Although many co-factors in the regulation of STAT3 activity have been identified, it remains unclear how STAT3 phosphorylation is negatively regulated. Here, we report that SIPAR (STAT3-Interacting Protein As a Repressor) inhibits STAT3 activity by accelerating its dephosphorylation. We observed that SIPAR directly interacted with STAT3 upon IL-6 stimulation. Moreover, over-expression of SIPAR reduced, whereas depletion enhanced, the level of phosphorylated STAT3. We further demonstrated that SIPAR inhibited the growth of melanoma cells by decreasing the level of phosphorylated STAT3 and the expression of its target genes. These results suggest that SIPAR, functioning as a new negative regulator, inhibits STAT3 activity by enhancing its dephosphorylation and represses melanoma progression. (C) 2013 Elsevier Inc All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324971800021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); 3; ARTICLE; 11; 2272-2280; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/219749]
专题	生命科学学院
推荐引用方式 GB/T 7714	Ren, Fangli,Su, Fuqin,Ning, Hongxiu,et al. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma[J]. cellular signalling,2013.
APA	Ren, Fangli.,Su, Fuqin.,Ning, Hongxiu.,Wang, Yangmeng.,Geng, Yongtao.,...&Chang, Zhijie.(2013).SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.cellular signalling.
MLA	Ren, Fangli,et al."SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma".cellular signalling (2013).