Effects of calcitonin gene-related peptide-(8-37) on withdrawal   responses in rats with inflammation

doi:10.1016/S0014-2999(98)00102-2

CORC > 北京大学 > 生命科学学院

	Effects of calcitonin gene-related peptide-(8-37) on withdrawal responses in rats with inflammation
	Yu, LC ; Hansson, P ; Lundeberg, S ; Lundeberg, T
刊名	european journal of pharmacology
	1998
关键词	inflammation carrageenan hindpaw withdrawal latency intrathecal injection (CGRP-8-37) (calcitonin gene-related peptide-8-37) morphine CARRAGEENAN-INDUCED HYPERALGESIA ANTAGONIST CGRP(8-37) INCREASES Y-LIKE IMMUNOREACTIVITY JOINT SYNOVIAL-FLUID DORSAL HORN NEURONS NEUROKININ-A-LIKE SUBSTANCE-P-LIKE SPINAL-CORD KNEE-JOINT PERIPHERAL MONONEUROPATHY
DOI	10.1016/S0014-2999(98)00102-2
英文摘要	The present study was performed to explore the effect of subcutaneous injection of carrageenan into the rat plantar region on hindpaw edema formation and the latency of hindpaw withdrawal to presumed nociceptive stimulation. Subcutaneous injection of carrageenan into the left hindpaw induced a significant increase in the volume of the left hindpaw, leaving the right side unaffected. In addition, we found a bilateral decrease in hindpaw withdrawal latency to heat and mechanical, but not to cold stimulation. The decreased bilateral hindpaw withdrawal latency to heat stimulation lasted for 14 days after carrageenan injection. The decreased bilateral hindpaw withdrawal latency to mechanical stimulation lasted for 2 days after the injection, then reversed and increased from day 3 to 14. Intrathecal injection of either 10 nmol of calcitonin gene-related peptide 8-37 or 26.6 nmol of morphine induced significant bilateral increases in hindpaw withdrawal latency, which were more pronounced with the morphine. The results show that experimentally induced unilateral hindpaw inflammation induces a bilateral decrease in hindpaw withdrawal latencies to presumed nociceptive stimulation while the sensory systems for heat and mechanical stimulation were differently affected after carrageenan injection. (C) 1998 Elsevier Science B.V.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000073782400021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Pharmacology & Pharmacy; SCI(E); 22; ARTICLE; 2-3; 275-282; 347
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/217001]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yu, LC,Hansson, P,Lundeberg, S,et al. Effects of calcitonin gene-related peptide-(8-37) on withdrawal responses in rats with inflammation[J]. european journal of pharmacology,1998.
APA	Yu, LC,Hansson, P,Lundeberg, S,&Lundeberg, T.(1998).Effects of calcitonin gene-related peptide-(8-37) on withdrawal responses in rats with inflammation.european journal of pharmacology.
MLA	Yu, LC,et al."Effects of calcitonin gene-related peptide-(8-37) on withdrawal responses in rats with inflammation".european journal of pharmacology (1998).