Repeated massage-like stimulation induces long-term effects on   nociception: contribution of oxytocinergic mechanisms (Retracted   article. See vol. 29, pg. 868, 2009)

doi:10.1046/j.1460-9568.2002.02087.x

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	Repeated massage-like stimulation induces long-term effects on nociception: contribution of oxytocinergic mechanisms (Retracted article. See vol. 29, pg. 868, 2009)
	Lund, I ; Yu, LC ; Uvnas-Moberg, K ; Wang, J ; Yu, C ; Kurosawa, M ; Agren, G ; Rosen, A ; Lekman, M ; Lundeberg, T
刊名	european journal of neuroscience
	2002
关键词	hot-plate massage oxytocin PAG Randall Selitto RIA sensory stimulation stroking withdrawal latencies INDUCED ANALGESIA PERIAQUEDUCTAL GRAY SENSORY STIMULATION ANESTHETIZED RATS SPINAL-CORD BRAIN-STEM PAIN INCREASES LATENCY SYSTEM
DOI	10.1046/j.1460-9568.2002.02087.x
英文摘要	Massage-like stroking induces acute antinociceptive effects that can be reversed by an oxytocin antagonist, indicating activation of oxytocin on endogenous pain controlling systems. We now demonstrate an increase in hindpaw withdrawal latencies (HWLs), in response to thermal and mechanical stimuli, which was present after six treatments of massage-like stroking every other day and which continued to increase through the remaining seven treatments. Repeated massage-like stroking also resulted in increased oxytocin-like immunoreactivity (oxytocin-LI) levels in plasma and periaquaductal grey matter (PAG). Furthermore, increases in HWLs were also present after injections of oxytocin into the PAG (0.1, 0.5 and 1.0 nmol). Intra-PAG oxytocin injection of 1 nmol followed by 1 or 20 nmol of naloxone attenuated the increments in HWL. Also, there was a dose-dependent attenuation of the oxytocin-induced antinociceptive effects following intra-PAG injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI) but not the delta-antagonist naltrindole. The long-term antinociceptive effects of massage-like stroking may be attributed, at least partly, to the oxytocinergic system and its interaction with the opioid system, especially the mu- and the kappa-receptors in the PAG.; Neurosciences; SCI(E); 0; ARTICLE; 2; 330-338; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/209179]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lund, I,Yu, LC,Uvnas-Moberg, K,et al. Repeated massage-like stimulation induces long-term effects on nociception: contribution of oxytocinergic mechanisms (Retracted article. See vol. 29, pg. 868, 2009)[J]. european journal of neuroscience,2002.
APA	Lund, I.,Yu, LC.,Uvnas-Moberg, K.,Wang, J.,Yu, C.,...&Lundeberg, T.(2002).Repeated massage-like stimulation induces long-term effects on nociception: contribution of oxytocinergic mechanisms (Retracted article. See vol. 29, pg. 868, 2009).european journal of neuroscience.
MLA	Lund, I,et al."Repeated massage-like stimulation induces long-term effects on nociception: contribution of oxytocinergic mechanisms (Retracted article. See vol. 29, pg. 868, 2009)".european journal of neuroscience (2002).