Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle | |
Yang, JC ; Liu, J ; Yang, XW ; Tang, JG | |
刊名 | biotechnology letters
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2002 | |
关键词 | blood glucose diabetes mellitus electroporation gene therapy insulin-like protein IN-VIVO ADENOASSOCIATED VIRUS EXPRESSION VECTORS MICE EFFICIENCY CELLS |
DOI | 10.1023/A:1015506822817 |
英文摘要 | A naked plasmid with human pre-pro-insulin gene was transferred into skeletal muscle of diabetic rats by electric pulses and gene expression was detected. Blood glucose concentration was decreased from 24 mmol l(-1) to 8.5 mmol l(-1). Circulating insulin-like protein was increased significantly to 15-20 muU ml(-1), while that of the control group injected with the empty vector remained at less than 10 muU ml(-1). The low blood glucose concentration lasted for more than two months. These studies indicate that electroporational transfer of plasmid with human pre-pro-insulin gene into skeletal muscle could be a potential method of gene therapy for human diabetes mellitus.; Biotechnology & Applied Microbiology; SCI(E); 5; ARTICLE; 10; 851-855; 24 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/208955] ![]() |
专题 | 生命科学学院 |
推荐引用方式 GB/T 7714 | Yang, JC,Liu, J,Yang, XW,et al. Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle[J]. biotechnology letters,2002. |
APA | Yang, JC,Liu, J,Yang, XW,&Tang, JG.(2002).Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle.biotechnology letters. |
MLA | Yang, JC,et al."Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle".biotechnology letters (2002). |
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