Antinociceptive role of galanin in periaqueductal grey of rats with   experimentally induced mononeuropathy

doi:10.1016/S0306-4522(00)00005-1

CORC > 北京大学 > 生命科学学院

	Antinociceptive role of galanin in periaqueductal grey of rats with experimentally induced mononeuropathy
	Wang, D ; Lundeberg, T ; Yu, LC
刊名	neuroscience
	2000
关键词	galanin opioid peptides periaqueductal grey mononeuropathy antinociception hindpaw withdrawal latency SCIATIC-NERVE SECTION SPINAL-CORD PERIPHERAL MONONEUROPATHY RECEPTOR ANTAGONISTS MESSENGER-RNA DORSAL HORN NEUROPEPTIDE MORPHINE PAIN EXPRESSION
DOI	10.1016/S0306-4522(00)00005-1
英文摘要	The present study was performed in rats with experimentally induced mononeuropathy after left common sciatic nerve ligation. The hindpaw withdrawal latencies to thermal and mechanical stimulation increased significantly after intra-periaqueductal grey injection of 2 or 3 nmol, but not 1 nmol of galanin in rats with mononeuropathy. Intraperitoneal administration of 4.5 mg/kg morphine induced significant increases in hindpaw withdrawal latencies to both noxious stimulation, which were attenuated by following intra-periaqueductal grey injection of 2 nmol of the galanin antagonist galantide. Furthermore, the antinociceptive effect induced by intra-periaqueductal grey injection of 26.6 nmol of morphine was attenuated significantly by following intra-periaqueductal gray administration of 2 nmol of galantide. The results demonstrated that in periaqueductal grey galanin plays an antinociceptive role in rats with mononeuropathy and galanin is involved in the mechanisms of opioid-induced antinociception. (C) 2000 IBRO. Published by Elsevier Science Ltd.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086204000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 38; ARTICLE; 4; 767-771; 96
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/201983]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, D,Lundeberg, T,Yu, LC. Antinociceptive role of galanin in periaqueductal grey of rats with experimentally induced mononeuropathy[J]. neuroscience,2000.
APA	Wang, D,Lundeberg, T,&Yu, LC.(2000).Antinociceptive role of galanin in periaqueductal grey of rats with experimentally induced mononeuropathy.neuroscience.
MLA	Wang, D,et al."Antinociceptive role of galanin in periaqueductal grey of rats with experimentally induced mononeuropathy".neuroscience (2000).