Blockade effects of (Nphe1)Nociceptin(1-13)-NH2 on anti-nociception   induced by intrathecal administration of nociceptin in rats

doi:10.1016/S0167-0115(01)00263-4

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	Blockade effects of (Nphe1)Nociceptin(1-13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats
	Lu, JT ; Huang, YH ; Palmer, PP ; Xie, GX ; Gabriel, A ; Grond, S ; Yu, LC
刊名	正规肽
	2001
关键词	opioid-receptor-like (ORL1) receptor (Nphe1)nociceptin(1-13)-NH2 nociceptin anti-nociception spinal cord RECEPTOR GENE FAMILY ORPHANIN FQ/NOCICEPTIN SPINAL-CORD FQ CLONING MEMBER MONONEUROPATHY ANALGESIA RESPONSES BRAIN
DOI	10.1016/S0167-0115(01)00263-4
英文摘要	The present study investigated the roles of the opioid-receptor-like (ORL1) receptor and its endogenous ligand nociceptin on nociception in the spinal cord of rats. Intrathecal administration of 10 nmol of nociceptin produced significant increases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulation. There were no significant changes of average maximum angles in inclined plane tests after intrathecal injection of 10 nmol of nociceptin in rats. The intrathecal nociceptin-induced increases in HWL were antagonized by intrathecal administration of (Nphel)Nociceptin(1-13)-NH2, a selective antagonist of ORL1 receptor, in a dose-dependent manner. The results demonstrated that ORL1 receptor is involved in the nociceptin-induced anti-nociceptive effect in the spinal cord of rats. (C) 2001 Elsevier Science B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000170719500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 16; ARTICLE; 1-3; 81-85; 101
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200552]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lu, JT,Huang, YH,Palmer, PP,et al. Blockade effects of (Nphe1)Nociceptin(1-13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats[J]. 正规肽,2001.
APA	Lu, JT.,Huang, YH.,Palmer, PP.,Xie, GX.,Gabriel, A.,...&Yu, LC.(2001).Blockade effects of (Nphe1)Nociceptin(1-13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats.正规肽.
MLA	Lu, JT,et al."Blockade effects of (Nphe1)Nociceptin(1-13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats".正规肽 (2001).