Involvement of opioid receptors in the CGRP8-37-induced inhibition of   the activity of wide-dynamic-range neurons in the spinal dorsal horn of   rats

doi:10.1002/jnr.20111

CORC > 北京大学 > 生命科学学院

	Involvement of opioid receptors in the CGRP8-37-induced inhibition of the activity of wide-dynamic-range neurons in the spinal dorsal horn of rats
	Yan, Y ; Yu, LC
刊名	journal of neuroscience research
	2004
关键词	calcitonin gene-related peptide (CGRP) wide-dynamic-range neurons iontophoretic application mu-opioid receptor kappa-opioid receptor GENE-RELATED PEPTIDE ANTAGONIST CGRP(8-37) INCREASES HINDPAW WITHDRAWAL LATENCY SUBSTANCE-P CORD LOCALIZATION RELEASE CGRP MONONEUROPATHY NOCICEPTION
DOI	10.1002/jnr.20111
英文摘要	The present study was performed to explore the involvement of opioid receptors in the calcitonin gene-related peptide 8-37 (CGRP8-37, an antagonist of CGRP receptor)-induced inhibition of the activity of wide-dynamic-range (WDR) neurons in the spinal dorsal horn of rats. Extracellular recording was performed with a multibarrelled glass micropipette, and the chemicals were delivered by micro-iontophoresis. The discharge frequency of WDR neurons was evoked by subcutaneous electrical stimulation applied to the ipsilateral hind-paw. Iontophoretic application of CGRP8-37 by an ejection current of 160 nA induced significant inhibition of the discharge frequency of WDR neurons. The inhibitory effect of CGRP8-37 on the activity of WDR neurons was attenuated by later iontophoretic application of the opioid antagonist naloxone. Furthermore, the effect of CGRP8-37 was attenuated by either iontophoretic application of the kappa-receptor antagonist norbinaltorphimine (nor-BNI) or the mu-receptor antagonist beta-funaltrexamine (beta-FNA) but not by the delta-receptor antagonist naltrindole. The results indicate that kappa- and mu-opioid receptors on the membrane of WDR neurons are involved in the modulation of CGRP8-37-induced antinociception in dorsal horn of the spinal cord in rats. (C) 2004 Wiley-Liss, Inc.; Neurosciences; SCI(E); PubMed; 9; ARTICLE; 1; 148-152; 77
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200321]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yan, Y,Yu, LC. Involvement of opioid receptors in the CGRP8-37-induced inhibition of the activity of wide-dynamic-range neurons in the spinal dorsal horn of rats[J]. journal of neuroscience research,2004.
APA	Yan, Y,&Yu, LC.(2004).Involvement of opioid receptors in the CGRP8-37-induced inhibition of the activity of wide-dynamic-range neurons in the spinal dorsal horn of rats.journal of neuroscience research.
MLA	Yan, Y,et al."Involvement of opioid receptors in the CGRP8-37-induced inhibition of the activity of wide-dynamic-range neurons in the spinal dorsal horn of rats".journal of neuroscience research (2004).