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	Involvement of oxytocin in spinal antinociception in rats with inflammation
	Yu, SQ ; Lundeberg, T ; Yu, LC
刊名	脑研究
	2003
关键词	oxytocin oxytocin receptor antinociception spinal cord inflammation opioid receptor BINDING-SITES NOCICEPTIVE THRESHOLDS WITHDRAWAL RESPONSES BETA-FUNALTREXAMINE PERIAQUEDUCTAL GREY INDUCED ANALGESIA ANTI-NOCICEPTION DORSAL HORN CORD VASOPRESSIN
DOI	10.1016/S0006-8993(03)03019-1
英文摘要	The present study was conducted on rats with inflammation induced by subcutaneous injection of carrageenan into the left hindpaw. Intrathecal administration of oxytocin produced dose-dependent increases in the hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with inflammation. The antinociceptive effect of oxytocin was blocked by intrathecal administration of atosiban, a selective oxytocin antagonist, indicating that oxytocin receptor mediates oxytocin-induced antinociception in the spinal cord. The oxytocin-induced antinociceptive effect was attenuated by intrathecal administration of the opioid antagonist naloxone, suggesting an involvement of the endogenous opioid system in oxytocin-induced antinociception in the spinal cord of rats with inflammation. Furthermore, the antinociceptive effect of oxytocin was attenuated by intrathecal injections of the mu-receptor antagonist beta-funaltrexamine and the kappa-receptor antagonist nor-binaltorphimine, but not by the delta-receptor antagonist naltrindole, illustrating that mu- and kappa-receptors, but not delta-receptor, are involved in oxytocin-induced antinociception in the spinal cord of rats with inflammation. Moreover, intrathecal administration of atosiban alone induced a hyperalgesia in rats with inflammation, indicating that endogenous oxytocin is involved in the transmission and regulation of nociceptive information in the spinal cord of rats with inflammation. The present study showed that both exogenous and endogenous oxytocin displayed antinociception in the spinal cord in rats with inflammation, and mu- and kappa-receptors were involved in oxytocin-induced antinociception. (C) 2003 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000185316100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 42; ARTICLE; 1-2; 13-22; 983
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200230]
专题	生命科学学院 心理与认知科学学院
推荐引用方式 GB/T 7714	Yu, SQ,Lundeberg, T,Yu, LC. Involvement of oxytocin in spinal antinociception in rats with inflammation[J]. 脑研究,2003.
APA	Yu, SQ,Lundeberg, T,&Yu, LC.(2003).Involvement of oxytocin in spinal antinociception in rats with inflammation.脑研究.
MLA	Yu, SQ,et al."Involvement of oxytocin in spinal antinociception in rats with inflammation".脑研究 (2003).

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