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	Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins
	Chen Wen ; Ji Jianguo ; Xu Xiaoman ; He Sizhi ; Ru Binggen
	2003
英文摘要	To investigate molecular mechanisms of human brain aging, brain proteins were isolated from postmortem human young and old brains and profiled by two-dimensional gel electrophoresis (2-DE). With the help of special software, five down-regulated protein spots in two-dimensional gel electrophoresis gels of old brains were found compared with young brains, four of which was identified as a protein similar to peroxiredoxin 2 (accession-numbered as gi | 13631440), two of stathmin (phosphoprotein p19) and apolipoprotein A-I precursor (apo-AI) by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Eight common proteins, whose expressions were not altered between young and old brains, were also identified. The possible relevance of changes was analyzed. This study shows that the contribution of proteomics could be valuable in experimental gerontology field.; SCI(E); PubMed; 0; ARTICLE; 4; 209-16; 21
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200089]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen Wen,Ji Jianguo,Xu Xiaoman,et al. Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins[J],2003.
APA	Chen Wen,Ji Jianguo,Xu Xiaoman,He Sizhi,&Ru Binggen.(2003).Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins..
MLA	Chen Wen,et al."Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins".(2003).

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