Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats | |
Cui, XY ; Lundeberg, T ; Yu, LC | |
刊名 | 脑研究
![]() |
2004 | |
关键词 | corticotropin-releasing factor (CRF) CRF receptor central nucleus of amygdala (CeA) antinociception hyperalgesia GENE-RELATED PEPTIDE PERIAQUEDUCTAL GRAY NERVOUS-SYSTEM PAIN BRAIN MONONEUROPATHY LOCALIZATION INVOLVEMENT PATHWAYS STRESS |
DOI | 10.1016/j.brainres.2003.09.050 |
英文摘要 | Corticotropin-releasing factor (CRT) plays important physiological functions in the central nervous system. The present study was performed to investigate the role of CRF and CRF receptor in nociceptive modulation in the central nucleus of amygdala (CeA) of rats. The hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation increased significantly after intra-CeA administration of 0.1 and 0.01 nmol of CRF, but not 0.001 nmol, indicating that CRF induces antinociceptive effects in the CeA of rats. The antinociceptive effect of CRF was attenuated by intra-CeA administration of 0.1 nmol alpha-hCRF(9-41), a selective CRF receptor antagonist, suggesting that the CRF-induced antinociception is mediated by the CRF receptors in the CeA. Furthermore, the HWL to both thermal and mechanical stimulation decreased significantly after intra-CeA administration of a-hCRF9-41 alone, suggesting an involvement of endogenous CRY in the CeA in nociceptive modulation. The present study demonstrated that both exogenous and endogenous CRF plays an antinociceptive effect in the CeA, the effect is mediated by CRF receptor. (C) 2003 Elsevier B.V. All rights reserved.; Neurosciences; SCI(E); PubMed; 14; ARTICLE; 1; 23-28; 995 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/200055] ![]() |
专题 | 生命科学学院 |
推荐引用方式 GB/T 7714 | Cui, XY,Lundeberg, T,Yu, LC. Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats[J]. 脑研究,2004. |
APA | Cui, XY,Lundeberg, T,&Yu, LC.(2004).Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats.脑研究. |
MLA | Cui, XY,et al."Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats".脑研究 (2004). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论