Role of corticotropin-releasing factor and its receptor in nociceptive   modulation in the central nucleus of amygdala in rats

doi:10.1016/j.brainres.2003.09.050

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	Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats
	Cui, XY ; Lundeberg, T ; Yu, LC
刊名	脑研究
	2004
关键词	corticotropin-releasing factor (CRF) CRF receptor central nucleus of amygdala (CeA) antinociception hyperalgesia GENE-RELATED PEPTIDE PERIAQUEDUCTAL GRAY NERVOUS-SYSTEM PAIN BRAIN MONONEUROPATHY LOCALIZATION INVOLVEMENT PATHWAYS STRESS
DOI	10.1016/j.brainres.2003.09.050
英文摘要	Corticotropin-releasing factor (CRT) plays important physiological functions in the central nervous system. The present study was performed to investigate the role of CRF and CRF receptor in nociceptive modulation in the central nucleus of amygdala (CeA) of rats. The hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation increased significantly after intra-CeA administration of 0.1 and 0.01 nmol of CRF, but not 0.001 nmol, indicating that CRF induces antinociceptive effects in the CeA of rats. The antinociceptive effect of CRF was attenuated by intra-CeA administration of 0.1 nmol alpha-hCRF(9-41), a selective CRF receptor antagonist, suggesting that the CRF-induced antinociception is mediated by the CRF receptors in the CeA. Furthermore, the HWL to both thermal and mechanical stimulation decreased significantly after intra-CeA administration of a-hCRF9-41 alone, suggesting an involvement of endogenous CRY in the CeA in nociceptive modulation. The present study demonstrated that both exogenous and endogenous CRF plays an antinociceptive effect in the CeA, the effect is mediated by CRF receptor. (C) 2003 Elsevier B.V. All rights reserved.; Neurosciences; SCI(E); PubMed; 14; ARTICLE; 1; 23-28; 995
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200055]
专题	生命科学学院
推荐引用方式 GB/T 7714	Cui, XY,Lundeberg, T,Yu, LC. Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats[J]. 脑研究,2004.
APA	Cui, XY,Lundeberg, T,&Yu, LC.(2004).Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats.脑研究.
MLA	Cui, XY,et al."Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats".脑研究 (2004).