Antinociceptive effects of galanin in the rat tuberomammillary nucleus   and the plasticity of galanin receptor 1 during hyperalgesia.

doi:10.1002/jnr.20206

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	Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia.
	Sun, YG ; Li, J ; Yang, BN ; Yu, LC
刊名	journal of neuroscience research
	2004
关键词	sciatic nerve chronic constriction injury mononeuropathy inflammation pain modulation thermal nociception testing MORPHINE ANTINOCICEPTION NOCICEPTIVE RESPONSES PERIAQUEDUCTAL GREY SPINAL-CORD HISTAMINE PAIN MONONEUROPATHY INFLAMMATION NEURONS MODULATION
DOI	10.1002/jnr.20206
英文摘要	Although the tuberomammillary nucleus (TM) is well defined in terms of anatomy and neurochemistry, little is known about its function in nociceptive modulation. There was an abundance of galanin-immunoreactive fibers in the TM, and galanin has been implicated in pain processing. The present study assessed the role of galanin in the modulation of nociception in the TM of rats. Intra-TM injection of galanin dose-dependently increased the hindpaw withdrawal latency of rats to a noxious thermal stimulus, indicating an antinociceptive role of galanin in the TM. The antinociceptive effect of galanin was blocked by a subsequent intra-TM injection of galantide, a putative galanin receptor antagonist, suggesting that the antinociceptive effect of galanin is mediated by galanin receptors. Moreover, there was abundant galanin receptor 1 (GalR1) in the TM, and the number of GalR1-positive neurons in the ipsilateral TM increased significantly after unilateral loose ligation of the sciatic nerve compared with the contralateral TM or the TM of intact rats. However, the number of GalR1-positive neurons was not significantly altered by carrageenan-induced inflammation, in either the ipsilateral or the contralateral TM. The results suggest that galanin and GalR1 in the TM may play important roles in pain regulation. (C) 2004 Wiley-Liss, Inc.; Neurosciences; SCI(E); PubMed; 10; ARTICLE; 5; 718-722; 77
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199989]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Sun, YG,Li, J,Yang, BN,et al. Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia.[J]. journal of neuroscience research,2004.
APA	Sun, YG,Li, J,Yang, BN,&Yu, LC.(2004).Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia..journal of neuroscience research.
MLA	Sun, YG,et al."Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia.".journal of neuroscience research (2004).