A20 is a potent inhibitor of TLR3-and Sendai virus-induced activation of   NF-kappa B and ISRE and IFN-beta promoter

doi:10.1016/j.febslet.2004.08.071

CORC > 北京大学 > 生命科学学院

	A20 is a potent inhibitor of TLR3-and Sendai virus-induced activation of NF-kappa B and ISRE and IFN-beta promoter
	Wang, YY ; Li, LY ; Han, KJ ; Zhai, ZH ; Shu, HB
刊名	欧洲生化学会联合会快报
	2004
关键词	toll-like receptor 3 IFN-beta interferon-stimulated response element NF-kappa B A20 ZINC-FINGER PROTEIN DEPENDENT GENE-EXPRESSION DOMAIN-CONTAINING ADAPTER TRANSCRIPTION FACTORS SIGNALING PATHWAY TNF RECEPTOR APOPTOSIS TRIF RIP RECRUITMENT
DOI	10.1016/j.febslet.2004.08.071
英文摘要	Toll-like receptor 3 (TLR3) recognizes dsRNA generated during viral infection and activation of TLR3 results in induction of type I interferons (IFNs) and cellular anti-viral response. TLR3 is associated with a TIR domain-containing adapter protein TRIF, which activates distinct downstream pathways leading to activation of NF-kappaB and ISRE sites in the promoters of type I IFNs. We show here that A20, a NF-kappaB-inducible zinc finger protein that has been demonstrated to be an inhibitor of TNF-induced NF-kappaB activation and a physiological suppressor of inflammatory response, potently inhibited TLR3- and Sendai virus-mediated activation of ISRE and NF-kappaB and IFN-beta promoter in reporter gene assays. A20 also inhibited TRIF-, but not its downstream signaling components TBK1-, IKKbeta-, and IKKepsilon-mediated activation of ISRE and NF-kappaB and IFN-beta promoter. Moreover, A20 interacted with TRIF in co-inummoprecipitation experiments. Finally, expression of A20 could be induced at protein level by Sendai virus infection. These data suggest that A20 targets TRIF to inhibit TLR3-mediated induction of IFN-beta transcription and functions as a feedback negative regulator for TLR3 signaling and cellular anti-viral response. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.; Biochemistry & Molecular Biology; Biophysics; Cell Biology; SCI(E); PubMed; 80; ARTICLE; 1-2; 86-90; 576
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199951]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, YY,Li, LY,Han, KJ,et al. A20 is a potent inhibitor of TLR3-and Sendai virus-induced activation of NF-kappa B and ISRE and IFN-beta promoter[J]. 欧洲生化学会联合会快报,2004.
APA	Wang, YY,Li, LY,Han, KJ,Zhai, ZH,&Shu, HB.(2004).A20 is a potent inhibitor of TLR3-and Sendai virus-induced activation of NF-kappa B and ISRE and IFN-beta promoter.欧洲生化学会联合会快报.
MLA	Wang, YY,et al."A20 is a potent inhibitor of TLR3-and Sendai virus-induced activation of NF-kappa B and ISRE and IFN-beta promoter".欧洲生化学会联合会快报 (2004).