Alterations in the substance P-induced anti-nociception in the central   nervous system of rats after morphine tolerance

doi:10.1016/j.neulet.2005.01.084

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	Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance
	Dong, XG ; Yu, LC
刊名	神经科学快报
	2005
关键词	anti-nociception substance P (SP) intracerebroventricular administration morphine tolerance hindpaw withdrawal latency ANTAGONIST CGRP(8-37) INCREASES WITHDRAWAL RESPONSES LATENCY DEPENDENCE
DOI	10.1016/j.neulet.2005.01.084
英文摘要	The present study investigated the alteration in intracerebroventricular administration of substance P-induced anti-nociception after morphine tolerance in rats. The nociceptive response latencies to noxious thermal and mechanical stimulation increased significantly after intracerebroventricular administration of SP in normal rats. The SP-induced anti-nociception decreased significantly in morphine-tolerant rats than that in opioid naive rats. The results demonstrated that SP induced significant anti-nociceptive effects in the brain in normal rats, and the SP-induced anti-nociception was attenuated significantly in morphine-tolerant rats than that in opioid naive rats, indicating an alteration in SP-induced anti-nociception in the brain after chronic morphine treatments. (c) 2005 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 4; ARTICLE; 1-2; 47-50; 381
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199751]
专题	生命科学学院
推荐引用方式 GB/T 7714	Dong, XG,Yu, LC. Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance[J]. 神经科学快报,2005.
APA	Dong, XG,&Yu, LC.(2005).Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance.神经科学快报.
MLA	Dong, XG,et al."Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance".神经科学快报 (2005).