Roles of oxytocin in spatial learning and memory in the nucleus basalis   of Meynert in rats

doi:10.1016/j.regpep.2004.02.017

CORC > 北京大学 > 生命科学学院

	Roles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats
	Wu, W ; Yu, LC
刊名	正规肽
	2004
关键词	oxytocin nucleus basalis of Meynert spatial learning oxytocin receptor Morris water maze CONDITIONED TASTE-AVERSION CENTRAL-NERVOUS-SYSTEM LONG-TERM DEPRESSION SOCIAL RECOGNITION CHOLINE-ACETYLTRANSFERASE EXCITOTOXIC LESIONS WATER MAZE RECEPTOR VASOPRESSIN MAGNOCELLULARIS
DOI	10.1016/j.regpep.2004.02.017
英文摘要	The present study was performed to explore the role of oxytocin (OT) in spatial learning and memory in the nucleus basalis of Meynert (NBM) of rats. The latency, distance and swimming path to find the platform were tested by Morris water maze and recorded by a video camera connected to a computer. Intra-NBM injections of 2 or 10 nmol of OT, but not 0.2 nmol of OT, induced significant increase on the latency of spatial learning. Rats receiving intra-NBM administrations of 2 or 10 nmol of OT showed a more random search pattern. There were no significant changes in the swimming speed in Morris water maze test after the injection of OT. Furthermore, the impaired effect of OT on the latency of spatial learning was blocked by intra-NBM injection of the selective OT antagonist Atosiban, indicating that the effect of OT was mediated by OT receptor in the NBM of rats. Moreover, there were no influences of OT or Atosiban on the retention performance in rats. The results suggest that OT plays an inhibitory role in spatial learning in the NBM; the effect is mediated by OT receptor. (C) 2004 Elsevier B.V. All rights reserved.; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 0; ARTICLE; 1-3; 119-125; 120
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199561]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wu, W,Yu, LC. Roles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats[J]. 正规肽,2004.
APA	Wu, W,&Yu, LC.(2004).Roles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats.正规肽.
MLA	Wu, W,et al."Roles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats".正规肽 (2004).