Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats | |
Xiong, W ; Yu, LC | |
刊名 | 神经科学快报
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2006 | |
关键词 | antinociception nucleus accumbens morphine opioid receptor hindpaw withdrawal latency NEUROPEPTIDE-Y PROFILES BINDING BRAIN PAIN |
DOI | 10.1016/j.neulet.2006.01.052 |
英文摘要 | It is well known that there are three types of opioid receptors, mu- (MOR), delta- (DOR), and kappa-opioid receptor (KOR) in the central nervous system. The present study investigated the involvement of opioid receptors in morphine-induced antinociception in the nucleus accumbens (NAc) of rats. The hindpaw withdrawal latencies to thermal and mechanical stimulation increased markedly after intra-NAc administration of morphine. The antinociceptive effects induced by morphine were dose-dependently inhibited by intra-NAc administration of the non-selective opioid receptor antagonist naloxone. Furthermore, the morphine-induced antinociception was significantly attenuated by subsequent intra-NAc injection of the MOR antagonist beta-funaltrexamine or the KOR antagonist nor-binaltorphimine, but not the DOR antagonist naltrindole. The results indicate that MOR and KOR, but not DOR are involved in the morphine-induced antinociception in the NAc of rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 12; ARTICLE; 1-2; 167-170; 399 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/199336] ![]() |
专题 | 生命科学学院 |
推荐引用方式 GB/T 7714 | Xiong, W,Yu, LC. Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats[J]. 神经科学快报,2006. |
APA | Xiong, W,&Yu, LC.(2006).Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.神经科学快报. |
MLA | Xiong, W,et al."Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats".神经科学快报 (2006). |
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