Involvements of mu- and kappa-opioid receptors in morphine-induced   antinociception in the nucleus accumbens of rats

doi:10.1016/j.neulet.2006.01.052

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	Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats
	Xiong, W ; Yu, LC
刊名	神经科学快报
	2006
关键词	antinociception nucleus accumbens morphine opioid receptor hindpaw withdrawal latency NEUROPEPTIDE-Y PROFILES BINDING BRAIN PAIN
DOI	10.1016/j.neulet.2006.01.052
英文摘要	It is well known that there are three types of opioid receptors, mu- (MOR), delta- (DOR), and kappa-opioid receptor (KOR) in the central nervous system. The present study investigated the involvement of opioid receptors in morphine-induced antinociception in the nucleus accumbens (NAc) of rats. The hindpaw withdrawal latencies to thermal and mechanical stimulation increased markedly after intra-NAc administration of morphine. The antinociceptive effects induced by morphine were dose-dependently inhibited by intra-NAc administration of the non-selective opioid receptor antagonist naloxone. Furthermore, the morphine-induced antinociception was significantly attenuated by subsequent intra-NAc injection of the MOR antagonist beta-funaltrexamine or the KOR antagonist nor-binaltorphimine, but not the DOR antagonist naltrindole. The results indicate that MOR and KOR, but not DOR are involved in the morphine-induced antinociception in the NAc of rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 12; ARTICLE; 1-2; 167-170; 399
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199336]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xiong, W,Yu, LC. Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats[J]. 神经科学快报,2006.
APA	Xiong, W,&Yu, LC.(2006).Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.神经科学快报.
MLA	Xiong, W,et al."Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats".神经科学快报 (2006).