Histone acetylation affects expression of cellular patterning genes in   the Arabidopsis root epidermis

doi:10.1073/pnas.0503143102

CORC > 北京大学 > 生命科学学院

	Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis
	Xu, CR ; Liu, C ; Wang, YL ; Li, LC ; Chen, WQ ; Xu, ZH ; Bai, SN
刊名	proceedings of the national academy of sciences of the united states of america
	2005
关键词	histone as a signaling mediator trichostatin A histone deacetylase positional cue chromatin immunoprecipitation LATERAL INHIBITION GENOME-WIDE DIFFERENTIATION DEACETYLATION CHROMATIN THALIANA TRICHOME CAPRICE YEAST FATE
DOI	10.1073/pnas.0503143102
英文摘要	The Arabidopsis root has a unique cellular pattern in its single-layered epidermis. Cells residing over the intercellular spaces between underlying cortical cells (H position) differentiate into hair cells, whereas those directly over cortical cells (N position) differentiate into non-hair cells. Recent studies have revealed that this cellular pattern is determined by interactions of six patterning genes CPC, ETC, GL2, GL3/EGL3, TTG, and WER, and that the position-dependent expression of the CPC, GL2, and WER genes is essential for their appropriate interactions. However, little is known about how the expressions of the pattern genes are determined. Here we show that trichostatin A (TSA) treatment of germinating Arabidopsis seedlings alters the cellular pattern of the root epidermis to induce hair cell development at nonhair positions. The effects of TSA treatment are rapid, reversible, concentration-dependent, and position-independent. TSA inhibition of histone deacetylase activity results in hyperacetylation of the core histones H3 and H4, and alters the expression levels and cell specific expression of the patterning genes CPC, GL2 and WER. Analysis of histone deacetylase mutant cellular patterning further verified the participation of histone acetylation in cellular patterning, and revealed that HDA18 is a key component in the regulatory machinery of the Arabidopsis root epidermis. We propose a working model to suggest that histone acetylation may function in mediating a positional cue to direct expression of the patterning genes in the root epidermal cells.; Multidisciplinary Sciences; SCI(E); PubMed; 71; ARTICLE; 40; 14469-14474; 102
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199104]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xu, CR,Liu, C,Wang, YL,et al. Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis[J]. proceedings of the national academy of sciences of the united states of america,2005.
APA	Xu, CR.,Liu, C.,Wang, YL.,Li, LC.,Chen, WQ.,...&Bai, SN.(2005).Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis.proceedings of the national academy of sciences of the united states of america.
MLA	Xu, CR,et al."Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis".proceedings of the national academy of sciences of the united states of america (2005).