Antinociceptive role of galanin in the spinal cord of rats with   inflammation an involvement of opioid systems

doi:10.1016/j.regpep.2005.09.002

CORC > 北京大学 > 生命科学学院

	Antinociceptive role of galanin in the spinal cord of rats with inflammation an involvement of opioid systems
	Xiong, W ; Gao, L ; Sapra, A ; Yu, LC
刊名	正规肽
	2005
关键词	galanin galanin receptor spinal antinociception opioid peptide inflammation PRIMARY SENSORY NEURONS PROTEIN-KINASE-C VASOACTIVE INTESTINAL POLYPEPTIDE DORSAL-HORN RECEPTOR ANTAGONISTS INTRATHECAL GALANIN ARCUATE NUCLEUS MORPHINE PAIN IMMUNOREACTIVITY
DOI	10.1016/j.regpep.2005.09.002
英文摘要	The present study investigated the role of galanin in the transmission of nociceptive information in the spinal cord of rats with inflammation. Bilateral decreases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulation were observed after acute inflammation induced by injection of carrageenan into the plantar region of the rat left hindpaw. Intrathecal injection of galanin induced significant increases in the HWLs to thermal and mechanical stimulation in rats with inflammation. The galanin-induced antinociceptive effect was more pronounced in rats with inflammation than that in intact rats. The antinociceptive effect of galanin was partly inhibited by intrathecal injection of naloxone. Furthermore, intrathecal administration of galantide, an antagonist of galanin receptor, could attenuate the antinociceptive effect induced by intraperitoneal injection of morphine, suggesting an involvement of opioid systems in the galanin-induced antinociception. The results indicate that galanin plays an important role in the transmission of nociceptive information in the spinal cord of rats with inflammation, and opioid systems are involved in the galanin-induced antinociception. (c) 2005 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233711500014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 17; ARTICLE; 1-3; 85-90; 132
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199073]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xiong, W,Gao, L,Sapra, A,et al. Antinociceptive role of galanin in the spinal cord of rats with inflammation an involvement of opioid systems[J]. 正规肽,2005.
APA	Xiong, W,Gao, L,Sapra, A,&Yu, LC.(2005).Antinociceptive role of galanin in the spinal cord of rats with inflammation an involvement of opioid systems.正规肽.
MLA	Xiong, W,et al."Antinociceptive role of galanin in the spinal cord of rats with inflammation an involvement of opioid systems".正规肽 (2005).