Involvement of mu- and delta-opioid receptors in the antinociceptive   effects induced by AMPA receptor antagonist in the spinal cord of rats

doi:10.1016/j.neulet.2006.03.071

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	Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats
	Kong, LL ; Yu, LC
刊名	神经科学快报
	2006
关键词	AMPA receptor antinociception hindpaw withdrawal latency intrathecal injection mu-opioid receptor delta-opioid receptor PAIN NMDA MORPHINE MODEL
DOI	10.1016/j.neulet.2006.03.071
英文摘要	The present study was performed to explore the involvement of opioid receptors in the antinociception induced by a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist in rats. The hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation was assessed by hot plate test and the Randall Selitto Test. Intrathecal injection of 20 nmol of 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo[f]quinoxaline-7-sulfonamide (NBQX) disodium, a competitive AMPA receptor antagonist, increased significantly the HWLs to both thermal and mechanical stimulation in rats. The increased HWLs induced by NBQX were dose-dependently attenuated by the opioid receptor antagonist naloxone, while naloxone itself had no marked influences on the HWL of rats. Furthermore, the increased HWLs induced by NBQX were inhibited by the mu-opioid antagonist beta-funaltrexamine (beta-FNA) or the delta-opioid antagonist naltrindole, but not by the kappa-opioid antagonist nor-binaltorphimine (nor-BNI). The results suggest that mu- and delta-opioid receptors, not kappa-opioid receptor, are involved in the antinociception induced by AMPA antagonist in the spinal cord of rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 0; ARTICLE; 1-2; 180-183; 402
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/198907]
专题	生命科学学院
推荐引用方式 GB/T 7714	Kong, LL,Yu, LC. Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats[J]. 神经科学快报,2006.
APA	Kong, LL,&Yu, LC.(2006).Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats.神经科学快报.
MLA	Kong, LL,et al."Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats".神经科学快报 (2006).