Involvement of opioid receptors in oxytocin-induced antinociception in   the nucleus accumbens of rats

doi:10.1016/j.jpain.2006.07.001

CORC > 北京大学 > 生命科学学院

	Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats
	Gu, Xing-Long ; Yu, Long-Chuan
刊名	journal of pain
	2007
关键词	antinociception hindpaw withdrawal latency naloxone nucleus accumbens opioid receptor oxytocin MESSENGER-RNA EXPRESSION NEUROPEPTIDE-Y PAIN SYSTEM STIMULATION NOCICEPTION ANALGESIA
DOI	10.1016/j.jpain.2006.07.001
英文摘要	Antinociceptive effects of oxytocin have been demonstrated in mice, rats, dogs, and humans. It has been shown that oxytocin receptors and fibers with oxytocin were distributed in the nucleus accumbens (NAc) of rats. The present study was performed to investigate the regulating role of oxytocin in nociception in the NAc of rats. Intra-NAc administration of oxytocin-induced dose-dependent increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats, indicating that oxytocin has antinociceptive effects in the NAc of rats. Furthermore, the oxytocin-induced antinociceptive effects were attenuated by intra-NAc administration of the opioid-receptor antagonist naloxone, suggesting that the endogenous opioid system is involved in the oxytocin-induced antinociception in the NAc. Moreover, the oxytocin-induced antinociception was attenuated by intra-NAc injection of the kappa-receptor antagonist nor-binaltorphimine (nor-BNI) and the mu-receptor antagonist P-funaltrexamine, but not by the delta-receptor antagonist naltrindole, demonstrating the involvements of mu- and kappa-receptors, but not delta-receptor, in the oxytocin-induced antinociception in the NAc of rats. Perspective: This article supplements the evidence that oxytocin regulates nociception in the central nervous system. It presents additional material for clinical application of oxytocin as an analgesia drug. (C) 2007 by the American Pain Society.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000244025700010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Clinical Neurology; Neurosciences; SCI(E); PubMed; 31; ARTICLE; 1; 85-90; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/198604]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gu, Xing-Long,Yu, Long-Chuan. Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats[J]. journal of pain,2007.
APA	Gu, Xing-Long,&Yu, Long-Chuan.(2007).Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats.journal of pain.
MLA	Gu, Xing-Long,et al."Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats".journal of pain (2007).