The role of intracellular amyloid beta in Alzheimer&apos;s disease

doi:10.1016/j.pneurobio.2007.08.002

CORC > 北京大学 > 生命科学学院

	The role of intracellular amyloid beta in Alzheimer's disease
	Li, Meng ; Chen, Liying ; Lee, Daniel Hong Seng ; Yu, Long-Chuan ; Zhang, Yan
刊名	神经生物学进展
	2007
关键词	Alzheimer&apos amyloid p peptide neurotoxicity neuronal loss INTRANEURONAL-A-BETA INCLUSION-BODY MYOSITIS ELECTRON-MICROSCOPIC LOCALIZATION TRANSGENIC MOUSE MODEL APOPTOTIC CELL-DEATH PRECURSOR PROTEIN ENDOPLASMIC-RETICULUM PLAQUE-FORMATION HUMAN NEURONS DOWN-SYNDROME s disease
DOI	10.1016/j.pneurobio.2007.08.002
英文摘要	Extracellular amyloid beta (A beta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, A beta also accumulates inside the AD neurons. This intracellular A beta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of A beta in AD. Therapeutics targeting intracellular A beta could be effective treatment for AD. (c) 2007 Elsevier Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 55; REVIEW; 3; 131-139; 83
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/198075]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Meng,Chen, Liying,Lee, Daniel Hong Seng,et al. The role of intracellular amyloid beta in Alzheimer's disease[J]. 神经生物学进展,2007.
APA	Li, Meng,Chen, Liying,Lee, Daniel Hong Seng,Yu, Long-Chuan,&Zhang, Yan.(2007).The role of intracellular amyloid beta in Alzheimer's disease.神经生物学进展.
MLA	Li, Meng,et al."The role of intracellular amyloid beta in Alzheimer's disease".神经生物学进展 (2007).