Antinociceptive effects of galanin in the central nucleus of amygdala of   rats, an involvement of opioid receptors

doi:10.1016/j.brainres.2009.12.060

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	Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors
	Jin, Wu-Yang ; Liu, Zhuo ; Liu, Dong ; Yu, Long-Chuan
刊名	脑研究
	2010
关键词	Antinociceptive effect Central nucleus of amygdala (CeA) Galanin Hindpaw withdrawal latency Mu-Opioid receptor Delta-Opioid receptor CENTRAL-NERVOUS-SYSTEM GENE-RELATED PEPTIDE ARCUATE NUCLEUS SPINAL ANTINOCICEPTION PERIAQUEDUCTAL GREY MESSENGER-RNA PREOPTIC AREA INTACT RATS PAIN HYPOTHALAMUS
DOI	10.1016/j.brainres.2009.12.060
英文摘要	The central nucleus of amygdala (CeA) is a very important brain structure involved in multiple physiological functions, especially in pain modulation. There are high densities of galanin and galanin receptors found in the CeA. The present study was performed to explore the antinociceptive effects of galanin in the CeA of rats, and possible involvements of opioid receptors in the galanin-induced antinociception. Intra-CeA injection of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Interestingly, the amtinociceptive effect induced by intra-CeA injection of galanin was blocked by intra-CeA injection of naloxone, a common opioid receptor antagonist, indicating an involvement of opioid receptors in the galanin-induced antinociception in the CeA of rats. Moreover, intra-CeA injection of either selective mu-opioid receptor antagonist beta-funaltrexamine (beta-FNA) or delta-opioid receptor antagonist naltrindole, but not kappa-opioid receptor antagonist nor-binaltorphimine (nor-BNI), significantly attenuated the galanin-induced increases in HWLs in the CeA of rats. Taken together, the results demonstrate that galanin induces antinociceptive effects in the CeA of rats, and both mu- and delta-opioid receptors are involved in the galanin-induced antinociception. (C) 2009 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000275451000003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 19; ARTICLE; 16-21; 1320
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/197418]
专题	生命科学学院
推荐引用方式 GB/T 7714	Jin, Wu-Yang,Liu, Zhuo,Liu, Dong,et al. Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors[J]. 脑研究,2010.
APA	Jin, Wu-Yang,Liu, Zhuo,Liu, Dong,&Yu, Long-Chuan.(2010).Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.脑研究.
MLA	Jin, Wu-Yang,et al."Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors".脑研究 (2010).