Immunotherapy with combined DNA vaccines is an effective treatment for   M. bovis infection in cattle

doi:10.1016/j.vaccine.2008.12.055

CORC > 北京大学 > 生命科学学院

	Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle
	Hu, Xi-Dan ; Chen, Su-Ting ; Yu, Da-Hai ; Li, Shu-Xia ; Cai, Hong
刊名	vaccine
	2009
关键词	Mycobacterium bovis Combined DNA vaccines Immunotherapy MYCOBACTERIUM-TUBERCULOSIS INFECTION DELTA T-CELLS MICE CHEMOTHERAPY RESPONSES VACCINATION IMMUNIZATION ANTIGENS MODEL AG85B
DOI	10.1016/j.vaccine.2008.12.055
英文摘要	Mycobacterium bovis causes tuberculosis in cattle. Because current therapies inadequately prevent disease spread, new therapies for M. bovis infections are urgently needed. We treated M. bovis-infected cattle with combinations of DNA vaccines, resulting in significantly reduced pulmonary bacterial loads compared with the untreated group. Further, the pathological changes of lungs were also slight and the lesions were limited in animals treated with the combined DNA vaccines, whereas untreated animals had extensive lung fibrosis and consolidated lesions. This is the first report of DNA vaccine used to treat M. bovis. Thus, combined DNA vaccines may provide enhanced immunotherapeutic efficacy for treatment of bovine tuberculosis. (C) 2009 Elsevier Ltd. All rights reserved.; Immunology; Medicine, Research & Experimental; SCI(E); PubMed; 7; ARTICLE; 9; 1317-1322; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/197292]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hu, Xi-Dan,Chen, Su-Ting,Yu, Da-Hai,et al. Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle[J]. vaccine,2009.
APA	Hu, Xi-Dan,Chen, Su-Ting,Yu, Da-Hai,Li, Shu-Xia,&Cai, Hong.(2009).Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle.vaccine.
MLA	Hu, Xi-Dan,et al."Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle".vaccine (2009).