ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune   signaling through dimerization

doi:10.1073/pnas.0900850106

CORC > 北京大学 > 生命科学学院

	ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
	Sun, Wenxiang ; Li, Yang ; Chen, Lu ; Chen, Huihui ; You, Fuping ; Zhou, Xiang ; Zhou, Yi ; Zhai, Zhonghe ; Chen, Danying ; Jiang, Zhengfan
刊名	proceedings of the national academy of sciences of the united states of america
	2009
关键词	innate immunity type I IFN functional cDNA library screening cytosolic RNA and dsDNA ER retention signal NF-KAPPA-B DOUBLE-STRANDED-RNA RIG-I ADAPTER PROTEIN ANTIVIRAL RESPONSE MEMBRANE-PROTEINS VIRUS RECOGNITION RECEPTORS DNA
DOI	10.1073/pnas.0900850106
英文摘要	We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non-self-cytosolic RNA and dsDNA. ERIS (also known as STING or MITA) resided exclusively on ER membrane. The ER retention/retrieval sequence RIR was found to be critical to retain the protein on ER membrane and to maintain its integrity. ERIS was dimerized on innate immune challenges. Coumermycin-induced ERIS dimerization led to strong and fast IFN induction, suggesting that dimerization of ERIS was critical for self-activation and subsequent downstream signaling.; Multidisciplinary Sciences; SCI(E); PubMed; 158; ARTICLE; 21; 8653-8658; 106
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/197251]
专题	生命科学学院
推荐引用方式 GB/T 7714	Sun, Wenxiang,Li, Yang,Chen, Lu,et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization[J]. proceedings of the national academy of sciences of the united states of america,2009.
APA	Sun, Wenxiang.,Li, Yang.,Chen, Lu.,Chen, Huihui.,You, Fuping.,...&Jiang, Zhengfan.(2009).ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.proceedings of the national academy of sciences of the united states of america.
MLA	Sun, Wenxiang,et al."ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization".proceedings of the national academy of sciences of the united states of america (2009).