Understanding the Mechanism of the Dormant Dauer Formation of C.   elegans: From Genetics to Biochemistry

doi:10.1002/iub.211

CORC > 北京大学 > 生命科学学院

	Understanding the Mechanism of the Dormant Dauer Formation of C. elegans: From Genetics to Biochemistry
	Wang, Yunbiao ; Ezemaduka, Anastasia N. ; Tang, Yan ; Chang, Zengyi
刊名	iubmb生命科学
	2009
关键词	Caenorhabditis elegans dormancy dauer metabolism DAF proteins heat shock proteins NEMATODE CAENORHABDITIS-ELEGANS CHAPERONE-LIKE ACTIVITY LARVAL DEVELOPMENT LIFE-SPAN SIGNALING PATHWAY DEVELOPMENTAL REGULATION FAMILY-MEMBER LONGEVITY RECEPTOR METABOLISM
DOI	10.1002/iub.211
英文摘要	Miner is a dormancy state that may occur at the end of developmental stage L1 or L2 of Caenorhabditis elegans when the environmental conditions are unfavorable (e.g., lack of food, high temperature, or overcrowding) for further growth. Dauer is a nonaging duration that does not affect the postdauer adult lifespan. Major molecular events would include the sensing of the environmental cues, the transduction of the signals into the cells, and the subsequent integration of the signals that result in the corresponding alteration of the metabolism and morphology of the organism. Genetics approach has been effectively used in identifying many of the so-called daf genes involved in dauer formation using C. elegans as the model. Nevertheless, biochemical studies at the protein and metabolic level has been lacking behind in understanding this important life phenomenon. This review focuses on the biochemical understanding so far achieved on dauer formation and dormancy in general, as well as important issues that need to he addressed in the future. (C) 2009 IUBMB IUBMB Life, 61(6): 607-612, 2009; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266676400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 11; REVIEW; 6; 607-612; 61
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/197237]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, Yunbiao,Ezemaduka, Anastasia N.,Tang, Yan,et al. Understanding the Mechanism of the Dormant Dauer Formation of C. elegans: From Genetics to Biochemistry[J]. iubmb生命科学,2009.
APA	Wang, Yunbiao,Ezemaduka, Anastasia N.,Tang, Yan,&Chang, Zengyi.(2009).Understanding the Mechanism of the Dormant Dauer Formation of C. elegans: From Genetics to Biochemistry.iubmb生命科学.
MLA	Wang, Yunbiao,et al."Understanding the Mechanism of the Dormant Dauer Formation of C. elegans: From Genetics to Biochemistry".iubmb生命科学 (2009).