Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in   Development, Ischemia and Post-Ischemia

doi:10.1007/s11064-010-0325-x

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	Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia
	Zhou, Ye ; Li, Hui Li ; Zhao, Rui ; Yang, Li Tao ; Dong, Yan ; Yue, Xin ; Ma, Yao Ying ; Wang, Zhuo ; Chen, Jianguo ; Cui, Cai Lian ; Yu, Albert Cheung-Hoi
刊名	神经化学研究
	2010
关键词	NOS1 MK-801 NR1 NR2 NITRIC-OXIDE SYNTHASE CEREBELLAR GRANULE NEURONS RAT HIPPOCAMPAL SLICES ER RETENTION SIGNAL NMDA RECEPTOR PRIMARY CULTURES IN-VITRO CORTICAL ASTROCYTES POSTNATAL-DEVELOPMENT GLUTAMATE RECEPTORS
DOI	10.1007/s11064-010-0325-x
英文摘要	The expression of the N-methyl-D-aspartate receptor (NMDA-R) in astrocytes is controversial. The receptor is commonly considered neuron-specific. We showed that astrocytes in primary cultures differentially expressed mRNA of NMDA-R subunits, NR1, NR2A and NR2B, in development, ischemia and post-ischemia. One-week-old cultures expressed detectable NR1 mRNA, which fell significantly at 2 weeks and became barely detectable at 4 weeks. NR2A and NR2B mRNA were both significantly up-regulated from 1 to 2 weeks. In 4 weeks, 2 h of ischemia caused a significant up-regulation of NR1 and NR2B mRNA; while 6 h caused down-regulation of NR2A mRNA. Under 3 h of post-ischemia, only NR1 mRNA was increased. Ischemia induced the expression of major NMDA-R effecter, nitric oxide synthase 1, which was unaffected by AMPA-R antagonist CNQX, but dose-dependently inhibited by NMDA-R specific antagonist MK-801. These findings reflected that astrocyte could express inducible functional NMDA receptors without the presence of neurons.; Biochemistry & Molecular Biology; Neurosciences; SCI(E); PubMed; 12; ARTICLE; 12,SI; 2124-2134; 35
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/195405]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhou, Ye,Li, Hui Li,Zhao, Rui,et al. Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia[J]. 神经化学研究,2010.
APA	Zhou, Ye.,Li, Hui Li.,Zhao, Rui.,Yang, Li Tao.,Dong, Yan.,...&Yu, Albert Cheung-Hoi.(2010).Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia.神经化学研究.
MLA	Zhou, Ye,et al."Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia".神经化学研究 (2010).