Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

doi:10.1016/j.cell.2011.09.022

CORC > 北京大学 > 生命科学学院

	Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
	Chen, Huihui ; Sun, Hui ; You, Fuping ; Sun, Wenxiang ; Zhou, Xiang ; Chen, Lu ; Yang, Jing ; Wang, Yutao ; Tang, Hong ; Guan, Yukun ; Xia, Weiwei ; Gu, Jun ; Ishikawa, Hiroki ; Gutman, Delia ; Barber, Glen ; Qin, Zhihai ; Jiang, Zhengfan
刊名	cell
	2011
关键词	NF-KAPPA-B RIG-I ADAPTER PROTEIN INTRACELLULAR DNA CYTOSOLIC DNA MAST-CELLS MICE EXPRESSION ALPHA INTERLEUKIN-4
DOI	10.1016/j.cell.2011.09.022
英文摘要	STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser(407) by TBK1 and Tyr(641), independent of JAKs. Phosphorylated STAT6 then dimerizes and translocates to the nucleus to induce specific target genes responsible for immune cell homing. Virus-induced STAT6 activation is detected in all cell-types tested, in contrast to the cell-type specific role of STAT6 in cytokine signaling, and Stat6(-/-) mice are susceptible to virus infection. Thus, STAT6 mediates immune signaling in response to both cytokines at the plasma membrane, and virus infection at the endoplasmic reticulum.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296199300020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 79; ARTICLE; 2; 436-446; 147
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/193815]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, Huihui,Sun, Hui,You, Fuping,et al. Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity[J]. cell,2011.
APA	Chen, Huihui.,Sun, Hui.,You, Fuping.,Sun, Wenxiang.,Zhou, Xiang.,...&Jiang, Zhengfan.(2011).Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity.cell.
MLA	Chen, Huihui,et al."Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity".cell (2011).