How does acetylation regulate autophagy?

doi:10.4161/auto.21156

CORC > 北京大学 > 生命科学学院

	How does acetylation regulate autophagy?
	Yi, Cong ; Yu, Li
刊名	autophagy
	2012
关键词	acetylation autophagy Atg3
DOI	10.4161/auto.21156
英文摘要	Mounting evidence suggests that acetylation plays an important role in various biological processes including transcriptional regulation, DNA damage repair, cell cycle progression, aging, and glycolysis. It is increasingly recognized that acetylation also regulates autophagy; for example, increasing the cellular acetylation level by treating cells with histone deacetylase (HDAC) inhibitors such as TSA can promote autophagy, and knockdown of the histone acetyltransferase KAT2B/p300 induces autophagy in nutrient-rich conditions. Our goal is to dissect the molecular mechanisms underlying the seemingly complicated role of acetylation in autophagy. We used Saccharomyces cerevisiae as a model organism because it can be genetically manipulated in a relatively easy and reliable way, allowing us to test the function of acetylases, deacetylases and acetylation sites on autophagy regulation in a "clean" system.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208891400016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); PubMed; 9; EDITORIAL MATERIAL; 10; 1529-1530; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/191192]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yi, Cong,Yu, Li. How does acetylation regulate autophagy?[J]. autophagy,2012.
APA	Yi, Cong,&Yu, Li.(2012).How does acetylation regulate autophagy?.autophagy.
MLA	Yi, Cong,et al."How does acetylation regulate autophagy?".autophagy (2012).