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	The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells
	Zhao, Ying ; Li, Xue ; Ma, Ke ; Yang, Jing ; Zhou, Jingyi ; Fu, Wan ; Wei, Fuzheng ; Wang, Lina ; Zhu, Wei-Guo
刊名	autophagy
	2013
关键词	FOXO1 XBP1u ERK autophagy cancer
DOI	10.4161/auto.23918
英文摘要	Earlier studies have shown that macroautophagy is not a constitutively activated process, however, the mechanism of activation is not fully understood. Here, we report that autophagy is a dynamic process in cancer cells in response to glucose starvation. In addition, we determined that FOXO1 turnover is involved in the regulation of this dynamic process. X-box binding protein 1u (XBP1u) plays a critical role in FOXO1 degradation by recruiting FOXO1 to the 20S proteasome. Moreover, the phosphorylation of XBP1u by mitogen-activated protein kinases 1 and 3 (MAPK1/3, also known as ERK2/1) on serine residues 61 and 176 was found to be essential for the enhancement of the interaction between XBP1u and FOXO1. Thus, our findings support the hypothesis that the turnover of FOXO1 induced by MAPK1/3 and XBP1u is a critical factor regulating the autophagic process.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000323174100019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); PubMed; 2; EDITORIAL MATERIAL; 5; 794-796; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/190670]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, Ying,Li, Xue,Ma, Ke,et al. The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells[J]. autophagy,2013.
APA	Zhao, Ying.,Li, Xue.,Ma, Ke.,Yang, Jing.,Zhou, Jingyi.,...&Zhu, Wei-Guo.(2013).The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells.autophagy.
MLA	Zhao, Ying,et al."The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells".autophagy (2013).

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