Lineage specifiers: new players in the induction of pluripotency

doi:10.1016/j.gpb.2013.09.005

CORC > 北京大学 > 生命科学学院

	Lineage specifiers: new players in the induction of pluripotency
	Shu Jian ; Deng Hongkui
刊名	genomics proteomics bioinformatics
	2013
关键词	Cell fate conversion,Lineage specifier,Pluripotency,Reprogramming,Seesaw model,iPSCs
DOI	10.1016/j.gpb.2013.09.005
英文摘要	Pluripotency-associated factors and their rivals, lineage specifiers, have long been considered the determining factors for the identity of pluripotent and differentiated cells, respectively. Therefore, factors that are employed for cellular reprogramming in order to induce pluripotency have been identified mainly from embryonic stem cell (ESC)-enriched and pluripotency-associated factors. Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. In this review, we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifiers. We highlight the value of the "seesaw" model in defining cellular identity, opening up a novel scenario to consider pluripotency and lineage specification.Copyright ? 2013. Production and hosting by Elsevier Ltd.; PubMed; 中国科学引文数据库(CSCD); 0; 5; 259-63; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189925]
专题	生命科学学院
推荐引用方式 GB/T 7714	Shu Jian,Deng Hongkui. Lineage specifiers: new players in the induction of pluripotency[J]. genomics proteomics bioinformatics,2013.
APA	Shu Jian,&Deng Hongkui.(2013).Lineage specifiers: new players in the induction of pluripotency.genomics proteomics bioinformatics.
MLA	Shu Jian,et al."Lineage specifiers: new players in the induction of pluripotency".genomics proteomics bioinformatics (2013).