Targeting Histone Deacetylases for Cancer Therapy: From Molecular   Mechanisms to Clinical Implications

doi:10.7150/ijbs.9067

CORC > 北京大学 > 生命科学学院

	Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications
	Li, Zhiming ; Zhu, Wei-Guo
刊名	international journal of biological sciences
	2014
关键词	HDAC HDAC inhibitor epigenetic therapy cancer DNA-DAMAGE RESPONSE HYPOXIA-INDUCIBLE FACTOR-1-ALPHA TO-MESENCHYMAL TRANSITION AUTOPHAGIC CELL-DEATH INHIBITOR DEPSIPEPTIDE GENE-EXPRESSION VALPROIC ACID CHROMATIN-STRUCTURE MEDIATED APOPTOSIS HDAC INHIBITOR
DOI	10.7150/ijbs.9067
英文摘要	Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, studies over the past decades have demonstrated that epigenetic regulation also participates in the development of cancer. The fundamental patterns of epigenetic components, such as DNA methylation and histone modifications, are frequently altered in tumor cells. Acetylation is one of the best characterized modifications of histones, which is controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDACs are a group of enzymes which catalyze the removal of the acetyl groups of both histones and non- histone proteins. HDACs are involved in modulating most key cellular processes, including transcriptional regulation, apoptosis, DNA damage repair, cell cycle control, autophagy, metabolism, senescence and chaperone function. Because HDACs have been found to function incorrectly in cancer, various HDAC inhibitors are being investigated to act as cancer chemotherapeutics. The primary purpose of this paper is to summarize recent studies of the links between HDACs and cancer, and further discuss the underlying mechanisms of anti- tumor activities of HDAC inhibitors and clinical implications.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339317100009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Biology; SCI(E); PubMed; 30; REVIEW; zhuweiguo@bjmu.edu.cn; 7; 757-770; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189286]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Zhiming,Zhu, Wei-Guo. Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications[J]. international journal of biological sciences,2014.
APA	Li, Zhiming,&Zhu, Wei-Guo.(2014).Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications.international journal of biological sciences.
MLA	Li, Zhiming,et al."Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications".international journal of biological sciences (2014).