Tcf712 Is Required for Left-Right Asymmetric Differentiation of   Habenular Neurons

doi:10.1016/j.cub.2014.08.006

CORC > 北京大学 > 生命科学学院

	Tcf712 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons
	Huesken, Ulrike ; Stickney, Heather L. ; Gestri, Gala ; Bianco, Isaac H. ; Faro, Ana ; Young, Rodrigo M. ; Roussigne, Myriam ; Hawkins, Thomas A. ; Beretta, Carlo A. ; Brinkmann, Irena ; Paolini, Alessio ; Jacinto, Raquel ; Albadri, Shahad ; Dreosti, Elena ; Tsalavouta, Matina ; Schwarz, Quenten ; Cavodeassi, Florencia ; Barth, Anukampa K. ; Wen, Lu ; Zhang, Bo ; Blader, Patrick ; Yaksi, Emre ; Poggi, Lucia ; Zigman, Mihaela ; Lin, Shuo ; Wilson, Stephen W. ; Carl, Matthias
刊名	current biology
	2014
关键词	NEUROANATOMICAL ASYMMETRIES ZEBRAFISH EMBRYOS BRAIN ASYMMETRY MIDBRAIN TARGET CELL-FATE PATHWAY LATERALITY SPECIFICATION NEUROGENESIS DIENCEPHALON
DOI	10.1016/j.cub.2014.08.006
英文摘要	Background: Although left-right asymmetries are common features of nervous systems, their developmental bases are largely unknown. In the zebrafish epithalamus, dorsal habenular neurons adopt medial (dHbm) and lateral (dHbl) subnuclear character at very different frequencies on the left and right sides. The left-sided parapineal promotes the elaboration of dHbl character in the left habenula, albeit by an unknown mechanism. Likewise, the genetic pathways acting within habenular neurons to control their asymmetric differentiated character are unknown. Results: In a forward genetic screen for mutations that result in loss of habenular asymmetry, we identified two mutant alleles of tcf712, a gene that encodes a transcriptional regulator of Wnt signaling. In tcf712 mutants, most neurons on both sides differentiate with dHbl identity. Consequently, the habenulae develop symmetrically, with both sides adopting a pronounced leftward character. Tcf712 acts cell automously in nascent equipotential neurons, and on the right side, it promotes dHbm and suppresses dHbl differentiation. On the left, the parapineal prevents this Tcf712-dependent process, thereby promoting dHbl differentiation. Conclusions: Tcf712 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 0; ARTICLE; s.wilson@ucl.ac.uk; matthias.carl@medma.uni-heidelberg.de; 19; 2217-2227; 24
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189156]
专题	生命科学学院
推荐引用方式 GB/T 7714	Huesken, Ulrike,Stickney, Heather L.,Gestri, Gala,et al. Tcf712 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons[J]. current biology,2014.
APA	Huesken, Ulrike.,Stickney, Heather L..,Gestri, Gala.,Bianco, Isaac H..,Faro, Ana.,...&Carl, Matthias.(2014).Tcf712 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons.current biology.
MLA	Huesken, Ulrike,et al."Tcf712 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons".current biology (2014).