Selective filtering defect at the axon initial segment in Alzheimer&apos;s   disease mouse models

doi:10.1073/pnas.1411837111

CORC > 北京大学 > 生命科学学院

	Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models
	Sun, Xiaqin ; Wu, Yu ; Gu, Mingxue ; Liu, Zhuo ; Ma, Yuanlin ; Li, Jun ; Zhang, Yan
刊名	proceedings of the national academy of sciences of the united states of america
	2014
关键词	AMYLOID-BETA NEURONAL POLARITY IN-VIVO PROTEIN PRESENILIN-1 TRANSPORT ANKYRIN(G) GENE CONTRIBUTES MAINTENANCE
DOI	10.1073/pnas.1411837111
英文摘要	Axon pathology has been widely reported in Alzheimer's disease (AD) patients and AD mouse models. Herein we report that increased miR-342-5p down-regulates the expression of ankyrin G (AnkG), a protein known to play a critical role in establishing selective filtering machinery at the axon initial segment (AIS). Diminished AnkG expression leads to defective AIS filtering in cultured hippocampal neurons from AD mouse models, as monitored by selective exclusion of large macromolecules from the axons. Furthermore, AnkG-deficiency impairs AIS localization of Na-v 1.6 channels and confines NR2B to the somatodendritic compartments. The expression of exogenous AnkG improved the cognitive performance of 12-mo-old APP/PS1 mice; thus, our data suggest that AnkG and impairment of AIS filtering may play important roles in AD pathology.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342350200061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 3; ARTICLE; yanzhang@pku.edu.cn; 39; 14271-14276; 111
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189126]
专题	生命科学学院
推荐引用方式 GB/T 7714	Sun, Xiaqin,Wu, Yu,Gu, Mingxue,et al. Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models[J]. proceedings of the national academy of sciences of the united states of america,2014.
APA	Sun, Xiaqin.,Wu, Yu.,Gu, Mingxue.,Liu, Zhuo.,Ma, Yuanlin.,...&Zhang, Yan.(2014).Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.proceedings of the national academy of sciences of the united states of america.
MLA	Sun, Xiaqin,et al."Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models".proceedings of the national academy of sciences of the united states of america (2014).