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Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models
Sun, Xiaqin ; Wu, Yu ; Gu, Mingxue ; Liu, Zhuo ; Ma, Yuanlin ; Li, Jun ; Zhang, Yan
刊名proceedings of the national academy of sciences of the united states of america
2014
关键词AMYLOID-BETA NEURONAL POLARITY IN-VIVO PROTEIN PRESENILIN-1 TRANSPORT ANKYRIN(G) GENE CONTRIBUTES MAINTENANCE
DOI10.1073/pnas.1411837111
英文摘要Axon pathology has been widely reported in Alzheimer's disease (AD) patients and AD mouse models. Herein we report that increased miR-342-5p down-regulates the expression of ankyrin G (AnkG), a protein known to play a critical role in establishing selective filtering machinery at the axon initial segment (AIS). Diminished AnkG expression leads to defective AIS filtering in cultured hippocampal neurons from AD mouse models, as monitored by selective exclusion of large macromolecules from the axons. Furthermore, AnkG-deficiency impairs AIS localization of Na-v 1.6 channels and confines NR2B to the somatodendritic compartments. The expression of exogenous AnkG improved the cognitive performance of 12-mo-old APP/PS1 mice; thus, our data suggest that AnkG and impairment of AIS filtering may play important roles in AD pathology.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342350200061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 3; ARTICLE; yanzhang@pku.edu.cn; 39; 14271-14276; 111
语种英语
内容类型期刊论文
源URL[http://ir.pku.edu.cn/handle/20.500.11897/189126]  
专题生命科学学院
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GB/T 7714
Sun, Xiaqin,Wu, Yu,Gu, Mingxue,et al. Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models[J]. proceedings of the national academy of sciences of the united states of america,2014.
APA Sun, Xiaqin.,Wu, Yu.,Gu, Mingxue.,Liu, Zhuo.,Ma, Yuanlin.,...&Zhang, Yan.(2014).Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.proceedings of the national academy of sciences of the united states of america.
MLA Sun, Xiaqin,et al."Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models".proceedings of the national academy of sciences of the united states of america (2014).
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