Oxidative Demethylation of DNA and RNA Mediated by Non-Heme   Iron-Dependent Dioxygenases

doi:10.1002/asia.201402148

CORC > 北京大学 > 生命科学学院

	Oxidative Demethylation of DNA and RNA Mediated by Non-Heme Iron-Dependent Dioxygenases
	Lu, Lining ; Zhu, Chenxu ; Xia, Bo ; Yi, Chengqi
刊名	chemistry an asian journal
	2014
关键词	demethylases dioxygenases DNA methylation DNA/RNA repair epigenetics non-heme iron REPAIR ENZYME ALKB ESCHERICHIA-COLI ALKB 2-HIS-1-CARBOXYLATE FACIAL TRIAD NUCLEIC-ACID DEMETHYLASE ACUTE MYELOID-LEUKEMIA OBESITY-ASSOCIATED FTO RESPONSE PROTEIN ALKB CRYSTAL-STRUCTURE THYMINE DNA BASE-J
DOI	10.1002/asia.201402148
英文摘要	DNA/RNA methylation can be generated by methyltransferases and thus plays a critical role in regulating cellular processes; alternatively, nucleic acid methylation can be produced by methylation agents and is cytotoxic/mutagenic if left unrepaired. Oxidative demethylation mediated by non-heme iron-dependent dioxygenases is an efficient way to reverse either the cellular roles of regulatory methylation or the cytotoxic/mutagenic effects of methylation damage. In this Focus Review we summarize recent advances in the study of nucleic acid dioxygenases exemplified by the TET and AlkB family proteins, with an emphasis on chemical insights from the recent literature. Comparison of the chemical mechanisms of these dioxygenases revealed that differences in the mechanism also contribute significantly to their distinct biological functions.; Chemistry, Multidisciplinary; SCI(E); EI; PubMed; 0; REVIEW; chengqi.yi@pku.edu.cn; 8,SI; 2018-2029; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188981]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lu, Lining,Zhu, Chenxu,Xia, Bo,et al. Oxidative Demethylation of DNA and RNA Mediated by Non-Heme Iron-Dependent Dioxygenases[J]. chemistry an asian journal,2014.
APA	Lu, Lining,Zhu, Chenxu,Xia, Bo,&Yi, Chengqi.(2014).Oxidative Demethylation of DNA and RNA Mediated by Non-Heme Iron-Dependent Dioxygenases.chemistry an asian journal.
MLA	Lu, Lining,et al."Oxidative Demethylation of DNA and RNA Mediated by Non-Heme Iron-Dependent Dioxygenases".chemistry an asian journal (2014).