Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions

doi:10.1016/j.febslet.2015.04.032

CORC > 北京大学 > 生命科学学院

	Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions
	Chen Hui-Min ; Yu Kai ; Tang Xiao-Yan ; Bao Zhao-Shi ; Jiang Tao ; Fan Xiao-Long ; Chen Xiao-Wei ; Su Xiao-Dong
刊名	欧洲生化学会联合会快报
	2015
关键词	Dimerization,Expression level,Fusion gene,Hepatocyte growth factor receptor,Phosphorylation,Receptor-type tyrosine-protein phosphatase zeta
DOI	10.1016/j.febslet.2015.04.032
英文摘要	PTPRZ1-MET (ZM) proteins are a group of fusion proteins identified in human gliomas by high-throughput transcriptome sequencing. ZM fusions are associated with poor prognosis in afflicted glioma patients and mediate oncogenic effects in assays. In this study, we show that ZM-carrying patients have increased hepatocyte growth factor receptor (MET) mRNA expression levels induced by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1). Furthermore, ZM fusions preserve fundamental properties of wild-type MET with respect to processing and dimerization, and enhance phosphorylation in an hepatocyte growth factor (HGF)-dependent and independent manner. Our findings suggest that ZM induces gliomas through elevated expression and phosphorylation of the MET oncoprotein.Copyright ? 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000354878000008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); PubMed; 2; ARTICLE; xdsu@pku.edu.cn
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/187985]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen Hui-Min,Yu Kai,Tang Xiao-Yan,et al. Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions[J]. 欧洲生化学会联合会快报,2015.
APA	Chen Hui-Min.,Yu Kai.,Tang Xiao-Yan.,Bao Zhao-Shi.,Jiang Tao.,...&Su Xiao-Dong.(2015).Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions.欧洲生化学会联合会快报.
MLA	Chen Hui-Min,et al."Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions".欧洲生化学会联合会快报 (2015).