HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

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	HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics
	Pan, Chungen ; Liu, Shuwen ; Jiang, Shibo
刊名	journal of the formosan medical association
	2010
关键词	fusion inhibitor gp41 HIV-1 peptide therapeutics IMMUNODEFICIENCY-VIRUS TYPE-1 6-HELIX BUNDLE FORMATION TERMINAL COILED-COIL D-PEPTIDE INHIBITORS CORE STRUCTURE ENTRY INHIBITORS IN-VITRO MEMBRANE-FUSION CELL-FUSION TRANSMEMBRANE GLYCOPROTEIN
英文摘要	Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glycoprotein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit. These changes include insertion of fusion peptide into the target cell membrane and association of C-heptad repeat (CHR) peptide with the N-heptad repeat (NHR) trimer, a pre-hairpin fusion intermediate. A stable six-helix bundle core is then formed, bringing the viral envelope and target cell membrane into close proximity for fusion. Peptides derived from the CHR region, such as T20 and C34, inhibit HIV-1 fusion by interacting with the gp41 fusion intermediate. A number of anti-HIV-1 peptides and small molecule compounds targeting the gp41 NHR-trimer have been identified. By combining HIV fusion/entry inhibitors targeting different sites in the gp41 fusion intermediate, a potent synergistic effect takes place, resulting in a potential new therapeutic strategy for the HIV infection/AIDS. Here, we present an overview of the current development of anti-HIV drugs, particularly those targeting the gp41 fusion intermediate. [J Formos Med Assoc 2010;109(2):94-105]; Medicine, General & Internal; SCI(E); 0; REVIEW; 2; 94-105; 109
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162692]
专题	生命科学学院
推荐引用方式 GB/T 7714	Pan, Chungen,Liu, Shuwen,Jiang, Shibo. HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics[J]. journal of the formosan medical association,2010.
APA	Pan, Chungen,Liu, Shuwen,&Jiang, Shibo.(2010).HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics.journal of the formosan medical association.
MLA	Pan, Chungen,et al."HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics".journal of the formosan medical association (2010).