Genetics of GABAergic signaling in nicotine and alcohol dependence

doi:10.1007/s00439-011-1108-4

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	Genetics of GABAergic signaling in nicotine and alcohol dependence
	Cui, Wen-Yan ; Seneviratne, Chamindi ; Gu, Jun ; Li, Ming D.
刊名	human genetics
	2012
关键词	GENOME-WIDE ASSOCIATION GABA(B) RECEPTOR MODULATION LINKAGE SCAN ENVIRONMENT INTERACTIONS SUSCEPTIBILITY LOCI EUROPEAN-AMERICANS AFRICAN-AMERICANS CENTRAL AMYGDALA CANDIDATE GENE COMBINATORIAL APPROACH
DOI	10.1007/s00439-011-1108-4
英文摘要	Both nicotine and alcohol addictions are common chronic brain disorders that are of great concern to individuals and society. Although genetics contributes significantly to these disorders, the susceptibility genes and variants underlying them remain largely unknown. Many years of genome-wide linkage and association studies have implicated a number of genes and pathways in the etiology of nicotine and alcohol addictions. In this communication, we focus on current evidence, primarily from human genetic studies, supporting the involvement of genes and variants in the GABAergic signaling system in the etiology of nicotine dependence and alcoholism based on linkage, association, and gene-by-gene interaction studies. Current efforts aim not only to replicate these findings in independent samples, but also to identify which variant contributes to the detected associations and through what molecular mechanisms.; Genetics & Heredity; SCI(E); 0; REVIEW; 6,SI; 843-855; 131
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162676]
专题	生命科学学院
推荐引用方式 GB/T 7714	Cui, Wen-Yan,Seneviratne, Chamindi,Gu, Jun,et al. Genetics of GABAergic signaling in nicotine and alcohol dependence[J]. human genetics,2012.
APA	Cui, Wen-Yan,Seneviratne, Chamindi,Gu, Jun,&Li, Ming D..(2012).Genetics of GABAergic signaling in nicotine and alcohol dependence.human genetics.
MLA	Cui, Wen-Yan,et al."Genetics of GABAergic signaling in nicotine and alcohol dependence".human genetics (2012).