CHD4/NuRD maintains demethylation state of rDNA promoters through   inhibiting the expression of the rDNA methyltransferase recruiter TIP5

doi:10.1016/j.bbrc.2013.06.045

CORC > 北京大学 > 生命科学学院

	CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5
	Ling, Te ; Xie, Wenbing ; Luo, Min ; Shen, Meili ; Zhu, Qiaoyun ; Zong, Le ; Zhou, Tingting ; Gu, Jun ; Lu, Zhigang ; Zhang, Feixiong ; Tao, Wei
刊名	生物化学与生物物理学研究通讯
	2013
关键词	rRNA genes TIP5 NoRC DNA methylation Reprogramming REMODELING COMPLEX NORC RIBOSOMAL-RNA GENES POLYMERASE-I TRANSCRIPTION DNA METHYLATION NONCODING RNA CHROMATIN NURD PROTEIN MI-2-BETA BIOLOGY
DOI	10.1016/j.bbrc.2013.06.045
英文摘要	Despite the well-established fact that NuRD (nucleosome remodeling and histone deacetylase) is incapable of actively demethylating DNA, the complex is surprisingly showed to be required for the establishment of unmethylated state at promoters of ribosomal genes. But the molecular mechanism underlying how NuRD mediates unmethylation at rDNA promoters remains obscure. Here we show that NuRD directly binds to the promoter of rDNA transcription silencer TIP5 (TTF-I interacting protein 5), one of the components of nucleolar remodeling complex NoRC that silences rRNA genes by recruiting DNA methyltransferase to rDNA promoters and increasing DNA methylation. NuRD negatively regulates TIP5 expression, thereby inhibiting rDNA methylation and maintaining demethylation state of rDNA promoters. The deficiency of NuRD components in reprogrammed cells activates TIP5 expression, resulting in the increased fraction of heterochromatic rRNA genes and transcriptional silencing. Thus, NuRD is able to control methylation status of rDNA promoters through crosstalking with NoRC complex. (c) 2013 Elsevier Inc. All rights reserved.; Biochemistry & Molecular Biology; Biophysics; SCI(E); 2; ARTICLE; 1; 101-107; 437
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162669]
专题	生命科学学院
推荐引用方式 GB/T 7714	Ling, Te,Xie, Wenbing,Luo, Min,et al. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5[J]. 生物化学与生物物理学研究通讯,2013.
APA	Ling, Te.,Xie, Wenbing.,Luo, Min.,Shen, Meili.,Zhu, Qiaoyun.,...&Tao, Wei.(2013).CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5.生物化学与生物物理学研究通讯.
MLA	Ling, Te,et al."CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5".生物化学与生物物理学研究通讯 (2013).