Calcitonin gene-related peptide 8-37 inhibits the evoked discharge   frequency of wide dynamic range neurons in dorsal horn of the spinal   cord in rats

doi:10.1016/S0167-0115(99)00046-4

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	Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats
	Yu, LC ; Zheng, EM ; Lundeberg, T
刊名	正规肽
	1999
关键词	calcitonin gene-related peptide (CGRP) nociceptive stimulation ANTAGONIST CGRP(8-37) INCREASES HINDPAW WITHDRAWAL LATENCY INFLAMMATION RESPONSES RELEASE INVIVO EXCITATION NALOXONE GALANIN
DOI	10.1016/S0167-0115(99)00046-4
英文摘要	The present study was performed to explore the effect of calcitonin gene-related peptide 8-37 (CGRP8-37) on the electrical stimulation-evoked discharge frequency of wide dynamic range (WDR) neurons in the dorsal horn of the spinal cord in rats. The discharge frequencies of WDR neurons were evoked by transdermic electrical stimulation applied on the ipsilateral hindpaw, CGRP8-37 was applied directly on the dorsal surface of the L3 to L5 spinal cord. After the administration of 3 nmol of CGRP8-37, the evoked discharge frequency of WDR neurons decreased significantly, an effect lasting more than 30 min. The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord. (C) 1999 Elsevier Science B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082492600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 18; ARTICLE; 1; 21-24; 83
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162648]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yu, LC,Zheng, EM,Lundeberg, T. Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats[J]. 正规肽,1999.
APA	Yu, LC,Zheng, EM,&Lundeberg, T.(1999).Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.正规肽.
MLA	Yu, LC,et al."Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats".正规肽 (1999).